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research 478 Mutation-specific siRNA Knockdown of GJB2 − Potential gene therapy for Keratitis-ichthyosis-deafness Syndrome

April 2017 in “Journal of Investigative Dermatology”

Targeted siRNA therapy may be a promising treatment for KID syndrome by reducing mutant gene expression and improving cell communication.

Oncogenic Ras Mutation Induces Spatiotemporally Specific Tissue Deformation Through Converting Fluctuated Into Sustained ERK Activation

research LB1011 Oncogenic ras mutation induces spatiotemporally specific tissue deformation through converting fluctuated into sustained ERK activation

July 2022 in “Journal of Investigative Dermatology”

A specific mutation in Kras causes abnormal tissue changes by making a cell signal continuously active, which disrupts normal cell coordination.

research Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75

6 citations , September 2015 in “Journal of Investigative Dermatology”

Using special RNA to target a mutant gene fixed hair problems in mice.

Oncogenic Kras Induces Spatiotemporally Specific Tissue Deformation Through Converting Pulsatile Into Sustained ERK Activation

research Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation

September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

The Kras mutation changes normal cell signals, leading to disrupted tissue structure and potential cancer.

Development of a New Therapeutic Approach Based on Peptide Nanoparticles Delivering CRISPR-Cas9 for the Specific Targeting of KRAS Mutations

research Development of a new therapeutic approach based on peptide nanoparticles delivering CRISPR-Cas9 for the specific targeting of KRAS mutations

September 2023 in “HAL (Le Centre pour la Communication Scientifique Directe)”

Peptide nanoparticles can effectively deliver CRISPR-Cas9 to target KRAS mutations in cancer.

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community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 2 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community 137 years old and still far more hair than the average r/tressless user

in Satire 1071 upvotes 3 years ago

The post and conversation are about a user claiming to be 137 years old with a full head of hair. Specific treatments mentioned include dutasteride, RU58841, and minoxidil.

community Why do we get bald from evolutionary perspective

in Chat 213 upvotes 1 year ago

Baldness is not an evolutionary disadvantage because it occurs after reproductive age. Treatments like Minoxidil and Finasteride are used for androgenetic alopecia but don't address the root cause.

community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

in Research/Science 370 upvotes 4 months ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

community Has anybody heard of this new cure?

in Treatment 2740 upvotes 6 months ago

A new hair loss treatment shows promise in mice but is unproven in humans. Effective treatments include finasteride and minoxidil.

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learn Epidermal Growth Factor

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