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GlossaryMyelosuppression

condition where bone marrow produces fewer blood cells

Myelosuppression is a medical condition where the bone marrow's ability to produce blood cells is decreased. This can lead to a reduction in red blood cells, white blood cells, and platelets, causing anemia, increased risk of infection, and bleeding problems. It is often a side effect of chemotherapy or radiation therapy used in cancer treatment.

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research Thiopurine-induced Myelosuppression with Severe Sepsis in a Patient with Crohn's Disease: A Case Report

5 citations , January 2021 in “Indian Journal of Critical Care Medicine”

Testing for the NUDT 15 variant is crucial before starting azathioprine, especially in Asians.

research Case report: NUDT15 polymorphism and severe azathioprine-induced myelosuppression in a young Chinese female with systematic lupus erythematosus: a case analysis and literature review

1 citations , May 2023 in “Frontiers in Pharmacology”

Genetic screening for NUDT15 polymorphisms is crucial for patients taking azathioprine, especially in Asians.

Managing Azathioprine-Induced Myelosuppression and Alopecia Totalis: Lessons from a Systemic Lupus Erythematosus Patient

research Managing Azathioprine-Induced Myelosuppression and Alopecia Totalis: Lessons from a SLE Patient

January 2024 in “Journal of Clinical Rheumatology and Immunology”

Monitor for early signs of myelosuppression, like hair loss, in patients on azathioprine to manage side effects.

A Case of Azathioprine Induced Severe Myelosuppression and Alopecia Totalis in IgA Nephropathy

research A Case of Azathioprine Induced Severe Myelosuppression and Alopecia Totalis in IgA Nephropathy

April 2017 in “Childhood Kidney Diseases”

Azathioprine can cause severe blood issues and hair loss, needing careful monitoring and possible discontinuation.

Pegylated Liposomal Doxorubicin: Metamorphosis of an Old Drug into a New Form of Chemotherapy

research Pegylated Liposomal Doxorubicin: Metamorphosis of an Old Drug into a New Form of Chemotherapy

522 citations , January 2001 in “Cancer investigation”

Doxil is an effective, modified chemotherapy drug with a unique toxicity profile and shows promise in treating certain cancers.

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