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GlossaryMyofibroblast Differentiation

process where fibroblasts transform into wound-healing myofibroblasts

Myofibroblast differentiation is the process by which fibroblasts, a type of cell found in connective tissue, transform into myofibroblasts. These myofibroblasts play a crucial role in wound healing and tissue repair by contracting and producing extracellular matrix components, which help close wounds and restore tissue integrity. However, excessive myofibroblast activity can lead to fibrosis, a condition characterized by excessive tissue scarring.

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research Dendritic Cell–Associated MARCKSL1 Regulates Fibroblast Differentiation During Wound Healing

March 2026 in “Wound Repair and Regeneration”

MARCKSL1 is important for wound healing and could be a target to reduce scarring.

$Fibroblasts: Immunomodulatory Factors in Refractory Diabetic Wound Healing$

research Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing

20 citations , August 2022 in “Frontiers in Immunology”

Fibroblasts are important in healing diabetic wounds, but high sugar levels can harm their function and slow down the healing process.

research Dual-Action Icariin-Containing Thermosensitive Hydrogel for Wound Macrophage Polarization and Hair-Follicle Neogenesis

6 citations , June 2022 in “Frontiers in Bioengineering and Biotechnology”

The gel with icariin speeds up wound healing, reduces scarring, and helps hair growth by controlling BMP4 signaling. It also reduces inflammation and improves wound quality in mice, adapts to different wound shapes, and gradually releases icariin to aid healing. It also prevents too much collagen and myofibroblast formation during skin healing.