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GlossaryMyofibroblast Differentiation

process where fibroblasts transform into wound-healing myofibroblasts

Myofibroblast differentiation is the process by which fibroblasts, a type of cell found in connective tissue, transform into myofibroblasts. These myofibroblasts play a crucial role in wound healing and tissue repair by contracting and producing extracellular matrix components, which help close wounds and restore tissue integrity. However, excessive myofibroblast activity can lead to fibrosis, a condition characterized by excessive tissue scarring.

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research Dual-Action Icariin-Containing Thermosensitive Hydrogel for Wound Macrophage Polarization and Hair Follicle Neogenesis

6 citations , June 2022 in “Frontiers in Bioengineering and Biotechnology”

The gel with icariin speeds up wound healing, reduces scarring, and helps hair growth by controlling BMP4 signaling. It also reduces inflammation and improves wound quality in mice, adapts to different wound shapes, and gradually releases icariin to aid healing. It also prevents too much collagen and myofibroblast formation during skin healing.

$Fibroblasts: Immunomodulatory Factors in Refractory Diabetic Wound Healing$

research Fibroblasts: Immunomodulatory Factors in Refractory Diabetic Wound Healing

20 citations , August 2022 in “Frontiers in Immunology”

Fibroblasts are important in healing diabetic wounds, but high sugar levels can harm their function and slow down the healing process.

research The Multifaceted Functions of TRPV4 and Calcium Oscillations in Tissue Repair

1 citations , January 2024 in “International journal of molecular sciences”

TRPV4 helps cells repair tissue and reduce scarring by controlling calcium levels.

research The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring

1 citations , March 2023 in “Pharmaceutics”

PBMCsec can help reduce and improve thick skin scars.

research Retinoids in Scarless Skin Regeneration: From Molecular Mechanisms to Therapeutic Strategies

September 2025 in “Frontiers in Cell and Developmental Biology”

Retinoic acid may help heal skin without scars by reducing fibrosis and supporting skin regeneration.

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community Topical Metformin for Hair Transplant donor area skin/hair regeneration?

in Research/Science 3 upvotes 9 months ago

Topical Metformin shows potential for regenerating hair follicles and minimizing scarring in hair transplant donor areas, similar to Verteporfin but without its side effects. The discussion suggests considering Metformin for post-hair transplant care, though more human trials are needed.

community The Real Reason For Hair Loss?

in Research/Science 1 week ago

Hair loss is linked to scalp fibrosis and tension, which result from chronic mechanical stress and androgenic signaling. Treatments include blocking androgens with finasteride, promoting hair growth with topical minoxidil, and improving scalp mobility through exercises.