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New mutations in hair keratin genes can change hair structure and cause monilethrix, with nail issues more common in certain gene mutations.

A new mutation in the KRT86 gene was found to cause the hair disorder monilethrix in a Han family.

Mutations in the hHb6 gene cause the hair disorder monilethrix.

5% topical minoxidil improves hair density and quality in monilethrix patients.

The Cyp11a1 gene variation has a weak link to PCOS, but higher di-hydro-testosterone levels are found in PCOS patients.