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research Nanocrystals of medium soluble actives—Novel concept for improved dermal delivery and production strategy
Nanocrystals improve skin penetration and stability of caffeine, suggesting a new method for delivering similar substances through the skin.
research Hair follicle targeting with curcumin nanocrystals: Influence of the formulation properties on the penetration efficacy
Curcumin nanocrystals in simple gels effectively penetrate hair follicles, but humectants can reduce this efficacy.
research Gallic Acid Nanocrystal Hydrogel: A Novel Strategy for Promoting Wound Healing and Inhibiting Scar Formation
The new gallic acid hydrogel speeds up wound healing and reduces scarring.
research Particle Size Effect of Curcumin Nanocrystals on Transdermal and Transfollicular Penetration by Hyaluronic Acid-Dissolving Microneedle Delivery
Smaller curcumin nanocrystals penetrate skin and hair follicles better than larger ones.
research Influence of nanocrystal size on the in vivo absorption kinetics of caffeine after topical application
Nanoparticles sized between 470 and 750 nm are best for delivering substances like caffeine into hair follicles for absorption.
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5 / 1000+ resultscommunity Crystals in Minoxidil bottle
Minoxidil bottle developed crystals, possibly due to air exposure, but the trichologist advised not to worry. The user questions the advice, noting the lack of recommendations for finasteride or derma rolling.
community I tried mixing 3 grams RU58841 into 60ml minoxidil 5% solution and shook for 5 minutes and I can still see tiny crystals floating around like a snow globe when I shine a torch in the bottle
OP mixed RU58841 with minoxidil and initially saw crystals, but realized they were bubbles. They asked for advice on application frequency for a 5% solution.
community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.
A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.
community Is the “crunching” sound during microneedling my scalp actually the needles cutting through hair?
The "crunching" sound during microneedling is likely the needles penetrating the scalp's outer layers, not cutting hair. Users suggest using a derma stamp instead of a roller to avoid potential hair damage.
community Group Buy for MR antagonist finerenone
User discusses group buy for finerenone, a third-gen mineralocorticoid antagonist for hair loss treatment. Finerenone inhibits TGFb, NOX, and ROS, and improves renal and cardiac function; topical dose should be no more than 10mg per day.