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research 5α-Reductases In Human Physiology: an Unfolding Story

44 citations , July 2012 in “Endocrine Practice”

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

research 5α-Reductases in Human Physiology: An Unfolding Story

November 2012 in “Endocrine Practice”

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

research The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer and Depression

75 citations , January 2014 in “Korean Journal of Urology”

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

research Finasteride treatment and neuroactive steroid formation.

9 citations , January 2009 in “PubMed”

Finasteride treatment can decrease certain steroids and increase others, possibly leading to depression symptoms in some cases.

research Changes in expression of the neuropeptide Y Y₁ receptor gene in the medial amygdala of transgenic mice during pregnancy and after delivery

12 citations , September 2002 in “Journal of Neurochemistry”

Pregnancy-related hormone changes affect Y1 receptor gene expression in mice.

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Community Join

5 / 15 results

community Finasteride does deplete important nuero-active steroids

in Research/Science 9 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community Why is Kevin Mann (Haircafe) Hated?

in Chat 62 upvotes 3 years ago

Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

in Finasteride/Dutasteride 26 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community risks with finasteride and dutasteride

in Research/Science 141 upvotes 1 year ago

Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

community Why do people here trust Kevin Mann?

in Chat 34 upvotes 6 years ago

Concerns about finasteride's side effects on neurosteroids and brain health, with skepticism towards Kevin Mann's advice. Users discuss using finasteride, minoxidil, and RU58841 for hair loss, with mixed opinions on their safety and effectiveness.

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