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GlossaryNLRP3 inflammasome

protein complex triggering inflammation in response to cellular stress

The NLRP3 inflammasome is a protein complex within cells that plays a crucial role in the body's immune response. It detects harmful stimuli, such as infections or cellular damage, and activates inflammatory processes to help fight off these threats. This complex is significant in various diseases, including autoimmune disorders and conditions like alopecia, where inflammation can affect hair follicles.

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research Spatiotemporal regulation of acute wound healing by the NLRP3 inflammasome: dual roles in macrophage-fibroblast chemotaxis and phenotype during wound repair

January 2026 in “Burns & Trauma”

NLRP3 helps control inflammation and repair in wound healing, making it a potential target for treatment.

PX-12 Inhibits NLRP3 Inflammasome Activation to Treat Psoriasis

research 1117 PX-12 inhibits NLRP3 inflammasome activation to treat psoriasis

April 2023 in “Journal of Investigative Dermatology”

PX-12 may help treat psoriasis by blocking inflammation and cell death.

NLRP1 Promotes Tumor Growth by Enhancing Inflammasome Activation and Suppressing Caspase-3 Activity in Human Melanoma

research 647 NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing caspase-3 activity in human melanoma

1 citations , April 2016 in “Journal of Investigative Dermatology”

NLRP1 helps melanoma tumors grow by boosting inflammasome activation and reducing caspase-3 activity.

Advancements in Research on the Immune-Inflammatory Mechanisms Mediated by NLRP3 Inflammasome in Ischemic Stroke and the Regulatory Role of Natural Plant Products

research Advancements in research on the immune-inflammatory mechanisms mediated by NLRP3 inflammasome in ischemic stroke and the regulatory role of natural plant products

18 citations , March 2024 in “Frontiers in Pharmacology”

Natural plant products like Proanthocyanidins and curcumin may help treat ischemic stroke by reducing inflammation.

research NFAT5 mediates hypertonic stress-induced atherosclerosis via activating NLRP3 inflammasome in endothelium

50 citations , August 2019 in “Cell Communication and Signaling”

NFAT5 triggers atherosclerosis under stress by activating inflammation in blood vessels.

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