6 citations
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January 2025 in “Differentiation” WNT10A is a secreted glycoprotein crucial for ectodermal organogenesis and tissue regeneration, with its significance first noted in 2006 in relation to cleft lip and palate. This review details the WNT10A gene and protein structure, expression patterns across species, and its roles in tissue and organ development. It highlights the connection between WNT10A loss-of-function mutations and human disorders such as ectodermal dysplasia syndromes, Odonto-oncho-dermal dysplasia, Schöpf-Schulz-Passarge syndrome, and selective tooth agenesis. Additionally, it discusses the association of increased WNT10A activity with conditions like fibrosis and carcinogenesis.
28 citations
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February 2010 in “British journal of dermatology/British journal of dermatology, Supplement” WNT10A mutations cause varied symptoms in patients with odonto-onycho-dermal dysplasia.
197 citations
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June 2009 in “American journal of human genetics” WNT10A mutations often cause ectodermal dysplasias, with males showing more tooth issues than females.
89 citations
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September 2010 in “Annual Review of Genomics and Human Genetics” The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.
June 1997 in “Australasian Journal of Dermatology” Researchers found new hair and nail genes, how hair reacts to UV, differences in white and pigmented hair growth, nerve changes in alopecia, treatments for baldness and alopecia, a toenail condition linked to a genetic disorder, and that nail fungus is more common in people with psoriasis.