February 2026 in “Biochemical and Biophysical Research Communications” This study demonstrates the successful regeneration of fully functional hair follicles using organ-inductive potential stem cells combined with an accessory mesenchymal cell population in an in vitro culture system. Researchers identified a specific cell population, PDGFRα+/Sca1+/CD34+ mesenchymal cells, from the boundary zone of the epithelial stem cell niche, which plays a crucial role in promoting the hair cycle's downgrowth phase. By reconstituting hair follicle germs from bulge region-derived epithelial stem cells, dermal papillae, and mesenchymal cells, the study achieved full-size hair follicle regeneration and hair cycling both in vitro and after skin transplantation. This research advances the understanding of adult organ-inductive potential stem cells and their niches, contributing to the fields of basic and medical science related to organ morphogenesis and the adult hair cycle.
January 2017 in “Springer eBooks” Scientists made working hair follicles using stem cells, helping future hair loss treatments.
21 citations
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June 2018 in “Current Opinion in Genetics & Development” Scientists have made progress in growing mini-organs and regenerating parts of the skin, with plans to treat hair loss in a future trial.
8 citations
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March 2019 in “Open Biology” The document concludes that regenerating functional ectodermal organs like teeth and hair is promising for future therapies.
15 citations
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February 2021 in “Scientific Reports” A specific group of stem cells can help regenerate hair continuously.