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GlossaryOrnithine Decarboxylase Inhibitors

compounds that block an enzyme crucial for cell growth

Ornithine Decarboxylase Inhibitors (ODC Inhibitors) are compounds that block the activity of the enzyme ornithine decarboxylase, which is crucial for the production of polyamines. Polyamines are molecules that play a key role in cell growth and differentiation. By inhibiting this enzyme, ODC Inhibitors can potentially slow down or prevent the proliferation of cells, making them useful in treatments for conditions like cancer and certain types of hair loss, such as androgenetic alopecia.

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research A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis

67 citations , September 2001 in “American Journal Of Pathology”

Inhibiting ODC can prevent UV-induced skin cancer.

research Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin

88 citations , August 1998 in “Carcinogenesis”

High levels of ODC and a mutant Ha-ras gene cause tumors in mice.

research Comprehensive clinical management of hirsutism

14 citations , March 2010 in “Gynecological endocrinology”

New treatments for excessive hair growth in women include insulin modulators and enzyme inhibitors.

research Contemporary medical therapy for polycystic ovary syndrome

31 citations , September 2006 in “International journal of gynaecology and obstetrics”

New treatments for PCOS focus on insulin resistance and reducing testosterone levels, along with traditional hormone therapies.

research Antizyme Release Is an Early Event in Ornithine Decarboxylase Induction by Hair Plucking

3 citations , February 1983 in “Journal of Investigative Dermatology”

Hair plucking quickly increases antizyme, reducing a specific enzyme activity in rats.

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community I am having Success with RU58841 and 1mm Derma Roller

in Microneedling 19 upvotes 4 years ago

A user reported success with RU58841 and a 1mm derma roller for hair regrowth, noting significant improvement in hair density and reduced scalp visibility. They also mentioned using minoxidil and black castor oil in the past, with mixed results.

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