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Did you mean p38 mitogen-activated protein kinase?

Glossaryp38 MAPK (p38 mitogen-activated protein kinase)

enzyme involved in cellular stress and inflammation responses

p38 MAPK, or p38 mitogen-activated protein kinase, is an enzyme that plays a crucial role in cellular responses to stress and inflammation. It is part of a signaling pathway that helps cells react to various external stimuli, such as UV radiation, heat shock, and cytokines, by regulating the expression of specific genes involved in inflammation, cell differentiation, and apoptosis (programmed cell death). This pathway is significant in various biological processes and diseases, including cancer, cardiovascular diseases, and inflammatory conditions.

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research Pathophysiology of Insulin Resistance and Related Skin Diseases ( Review Article)

2 citations , December 2024 in “Sohag Medical Journal”

Insulin resistance, characterized by decreased sensitivity of insulin-targeting tissues, affects skeletal muscle, liver, and adipose tissue, with muscle accounting for up to 70% of tissue glucose absorption. Insulin is crucial for skin physiology, regulating keratinocyte proliferation and differentiation necessary for epidermal structure development. The condition can be inherited, acquired, or mixed, and is linked to chronic inflammatory skin diseases like acne and psoriasis, where high proinflammatory cytokines activate p38 Mitogen activated protein kinases.

research Malva Verticillata Seed Extracts Upregulate the Wnt Pathway in Human Dermal Papilla Cells

25 citations , August 2015 in “International Journal of Cosmetic Science”

Malva verticillata seed extract might help treat hair loss by activating hair growth signals in skin cells.

research Type II Keratins Are Phosphorylated on a Unique Motif During Stress and Mitosis in Tissues and Cultured Cells

80 citations , June 2002 in “Molecular Biology of the Cell”

Type II keratins are uniquely phosphorylated during stress and mitosis, affecting their structure and function.

research Regulation of Involucrin Gene Expression

138 citations , June 2004 in “Journal of Investigative Dermatology”

Involucrin gene expression is controlled by specific proteins and signaling pathways.

research Enzymes

March 2008 in “British Journal of Pharmacology”

Enzymes play crucial roles in metabolism, health, and disease management.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Cell senescence-targeted treatment for hair loss, has anyone tried any products/enzymes etc. that use this theory

in Research/Science 5 upvotes 11 months ago

DHT causes hair loss by driving cells into senescence, and a polyphenol in black chokeberry may reverse this. A product using this theory is being considered for use alongside finasteride, minoxidil, and microneedling.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 739 upvotes 3 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Aronia Chokeberry and Cyanidin 3-O-arabinoside for Hair Growth (AGA) Study

in Research/Science 14 upvotes 2 years ago

A natural compound called C3A from Aronia Chokeberry can help prevent hair loss by counteracting the effects of DHT. The user has been taking 50 grams of dried organic Aronia Chokeberry daily for 30 days and will update with photos in 60 days.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 43 upvotes 6 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.