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RSPO1 mutations in certain patients lead to skin cells that don't develop properly and are more likely to become invasive, increasing the risk of skin cancer.

Nonpalmoplantar skin cells can be made to express keratin 9 by interacting with palmoplantar fibroblasts.

Clouston syndrome is inherited in an autosomal dominant pattern and caused by a specific gene mutation, with no current treatment available.

WNT10A mutations cause varied symptoms in patients with odonto-onycho-dermal dysplasia.

TRPV3 gene mutations cause Olmsted syndrome symptoms, but severity varies.