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PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

research PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis

26 citations , August 2019 in “Stem Cell Research & Therapy”

PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.

research Hoxc13 mutant mice lack external hair

245 citations , January 1998 in “Genes & Development”

Hoxc13 gene is essential for hair, nail, and papilla development.

research PBX1-SIRT1 Positive Feedback Loop Attenuates ROS-Mediated HF-MSC Senescence and Apoptosis

12 citations , August 2022 in “Stem cell reviews and reports”

Increasing PBX1 reduces aging and cell death in hair follicle stem cells by boosting SIRT1 and lowering PARP1 activity.

research Hoxc13 polyglycine repeat gain-of-function drives mammalian integument evolution by altering targeted genes and interactions

May 2026 in “Research Square”

The polyG fragment in Hoxc13 protein helps evolve mammalian skin and hair by enhancing gene interactions.

research Region-specific reversal of epidermal planar polarity in the rosette fancy mouse

2 citations , August 2023 in “Development”

Hair follicles in the back of the rosette fancy mouse have reversed orientations due to a gene mutation.

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