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      learn Pyrilutamide

      highly targeted anti-androgen that might have minimal systemic effects

      learn PP405

      mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

      learn Verteporfin

      chemical that might completely regrow follicles from hair transplant extractions

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      community Reasons why Topical worked but Oral Minoxidil didn’t?

      in Minoxidil  16 upvotes 2 years ago
      Some people find topical minoxidil effective for hair loss, but oral minoxidil doesn't work for them, possibly due to absorption issues. Others have had better results with oral minoxidil, suggesting individual responses vary.

      community A Short Recap on PP405 and AAD 2026

      in Update 1 week ago
      PP405 is a promising experimental topical treatment for alopecia that reactivates dormant hair follicles by targeting cellular energy, with large-scale trials planned for 2026. While it shows potential, it cannot regenerate permanently destroyed follicles, making hair transplants the only guaranteed solution for advanced baldness currently.