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GlossaryPerifollicular Lymphocytic Infiltrate

presence of immune cells around hair follicles

Perifollicular Lymphocytic Infiltrate refers to the presence of immune cells, specifically lymphocytes, around hair follicles. This condition is often seen in various types of hair loss disorders, such as alopecia areata, where the immune system mistakenly attacks the hair follicles, leading to hair loss.

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Perifollicular Inflammation and Fibrosis in Androgenetic Alopecia: Implications for Diagnosis and Treatment - A Comparative Histopathologic and Clinical Study with Normal-Appearing Scalp

research Perifollicular Inflammation and Fibrosis in Androgenetic Alopecia: Implications for Diagnosis and Treatment - A Comparative Histopathologic and Clinical Study with Normal-Appearing Scalp

January 2026 in “Clinical Cosmetic and Investigational Dermatology”

Early diagnosis and targeted anti-inflammatory treatments can improve outcomes in androgenetic alopecia with perifollicular inflammation and fibrosis.

research The Inflammatory Aspect of Male and Female Pattern Hair Loss

November 2020 in “DOAJ (DOAJ: Directory of Open Access Journals)”

Inflammation plays a key role in male and female pattern hair loss, and focusing on this could help develop better treatments.

research Discoid lupus alopecia complicated by frontal fibrosing alopecia on a background of androgenetic alopecia

25 citations , March 2013 in “British Journal of Dermatology”

Woman has discoid lupus, frontal fibrosing, and androgenetic alopecia.

Lichen Planopilaris: A Rare Inflammatory Cicatricial Alopecia

research Lichen planopilaris

April 2012 in “Informa Healthcare eBooks”

Lichen planopilaris is a rare, chronic condition causing hair loss, mainly in middle-aged women, and early treatment is important to prevent permanent baldness.

research A multicentre cohort study of the clinicopathological features and treatment outcomes of fibrosing alopecia in a pattern distribution

October 2025 in “Clinical and Experimental Dermatology”

Fibrosing alopecia can be stabilized or improved with anti-inflammatory treatments and hair growth agents.

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community Perifollicular Fibrosis and its role in androgenetic alopecia. Is Aminexil/Kopexil a must for anyone with AGA?

in Research/Science 4 upvotes 4 years ago

Aminexil/Kopexil may help reduce hair loss by addressing perifollicular fibrosis in androgenetic alopecia, but it lacks the extensive clinical backing of finasteride and minoxidil. Some users find it effective, but availability and cost are issues, especially in the US where it's not FDA-approved.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

in Research/Science 413 upvotes 1 year ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 50 upvotes 1 year ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

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