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GlossaryPhototoxicity

skin reaction from sunlight exposure to certain chemicals

Phototoxicity refers to a skin reaction that occurs when certain chemicals or medications on the skin are exposed to sunlight, leading to damage. This can result in redness, inflammation, and sometimes blistering, similar to a severe sunburn. For professionals, it's important to note that phototoxic reactions are typically caused by the interaction of ultraviolet (UV) light with photosensitizing agents, which can be found in some topical treatments, systemic medications, or even certain plant compounds.

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Research

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research Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications

23 citations , October 2008 in “Journal of medicinal chemistry”

PF-998425 is a new, effective, and non-phototoxic treatment for skin conditions related to androgens.

Successful Treatment of Resistant Alopecia Areata with a Phototoxic Dose of Ultraviolet A After Topical 8-Methoxypsoralen Application

research Successful treatment of resistant alopecia areata with a phototoxic dose of ultraviolet A after topical 8‐methoxypsoralen application

12 citations , January 2011 in “Photodermatology, photoimmunology & photomedicine”

This therapy effectively treats resistant alopecia areata with minimal side effects.

research Phototoxic reaction to oral terbinafine due to Tinea capitis in a child.

November 2024 in “PubMed”

Terbinafine can cause skin reactions when exposed to sunlight, so sun exposure should be avoided during treatment.

The Changing Patterns of Hair Density and Thickness in South Korean Women with Hair Loss: Clinical Office-Based Phototrichogram Analysis

research The changing patterns of hair density and thickness in South Korean women with hair loss: clinical office-based phototrichogram analysis

41 citations , December 2008 in “International Journal of Dermatology”

South Korean women with hair loss have lower hair density and thickness compared to healthy women.

Topical Valproic Acid Increases Hair Count in Male Patients with Androgenetic Alopecia: A Randomized, Comparative, Clinical Feasibility Study Using Phototrichogram Analysis

research Topical valproic acid increases the hair count in male patients with androgenetic alopecia: A randomized, comparative, clinical feasibility study using phototrichogram analysis

37 citations , February 2014 in “Journal of Dermatology”

Valproic acid increases hair count in men with hair loss.

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Community Join

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community Seeking Suggestions for VEGF Gene Therapy in Hair Transplants

in Basic Questions 75 upvotes 3 months ago

A user is exploring VEGF gene therapy to enhance hair transplant results, considering measuring hair shaft diameter and growth rate. Suggestions include using phototrichograms and possibly adding PRP, though its effectiveness is uncertain.

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