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GlossaryPilosebaceous Unit

complex skin structure including hair follicle and sebaceous gland

The pilosebaceous unit is a complex structure in the skin that includes a hair follicle, a sebaceous (oil) gland, and an arrector pili muscle. This unit is responsible for producing and growing hair, as well as secreting sebum, an oily substance that helps lubricate and protect the skin. Understanding the pilosebaceous unit is crucial for studying conditions like acne and alopecia, which involve disruptions in this system.

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The Distribution of Estrogen Receptor Beta Is Distinct to That of Estrogen Receptor Alpha and the Androgen Receptor in Human Skin and the Pilosebaceous Unit

research The Distribution of Estrogen Receptor Beta Is Distinct to That of Estrogen Receptor Alpha and the Androgen Receptor in Human Skin and the Pilosebaceous Unit

130 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

Estrogen Receptor ß (ERß) is the main hormone controller in human skin and hair follicles, not Estrogen Receptor α (ERα) or the Androgen Receptor (AR).

research Hormones and the Pilosebaceous Unit

97 citations , March 2009 in “Dermato-endocrinology”

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

research Hirsutism and the Variable Response of the Pilosebaceous Unit to Androgens

56 citations , August 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

Different women's hair and skin glands respond to hormones in varied ways, which can cause unwanted hair growth even with normal hormone levels, and more research is needed to treat this effectively.

research Traumatic Alopecia in Trichotillomania: A Pathogenic Interpretation of Histologic Lesions in the Pilosebaceous Unit

37 citations , April 1977 in “Journal of Cutaneous Pathology”

Skin biopsy can help diagnose hair loss from trichotillomania.

research Development and Characterization of Minoxidil-Loaded Liposomal System for Delivery to Pilosebaceous Units

34 citations , March 2004 in “Journal of Liposome Research”

Minoxidil-loaded liposomes effectively deliver to hair follicles, potentially improving hair growth and treating alopecia.

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community Why liposomal finasteride and minoxidil may be better than traditional topical solutions.

in Research/Science 2 upvotes 6 months ago

Liposomal formulations of finasteride and minoxidil may enhance drug delivery to the skin and hair follicles more effectively than traditional solutions, potentially improving treatment outcomes. However, more human clinical trials are needed to confirm these benefits.

community Opinions on Scalp fibrosis and DHT?

in Research/Science 9 upvotes 3 years ago

The conversation discusses the theory that scalp fibrosis contributes to male pattern baldness (MPB) by increasing DHT concentration, and mentions treatments like Minoxidil. The user seeks opinions on the theory and the effectiveness of scalp massages.

community Scalp tension and thickness of the galea aponeurotica, inflammation and potential treatment pathways

in Research/Science 3 years ago

Scalp tension potentially affecting hair loss, and potential treatments for male pattern baldness such as Minoxidil, Finasteride and RU58841. Evidence from a study was discussed which suggests that the cause of MPB lies within the follicle itself and is not dependent on its surrounding environment.

community The theory that explains everything. The malloclusion theory has been proven.

in Research/Science 26 upvotes 2 years ago

Brian Dye's theory links skeletal malocclusion type II to hair loss, suggesting it's a blood flow issue. Treatments mentioned include minoxidil, finasteride, and anti-inflammatory drugs like benaxoprofen.