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research The in vitro Assembly of Hair Follicle Keratins: Comparison of Cortex and Companion Layer Keratins

13 citations , January 2002 in “Biological chemistry”

Different conditions affect how hair proteins assemble, and certain mutations can change their structure.

research Structural Stability of Wild Type and Mutated α-Keratin Fragments: Molecular Dynamics and Free Energy Calculations

40 citations , September 2004 in “Biomacromolecules”

The Glu413Lys mutation in keratin affects hair stability, while Glu413Asp does not.

research Development of a mouse model for Hutchinson-Gilford progeria syndrome reveal defects in adult stem cell maintenance

March 2011 in “Open Archive (Karolinska Institutet)”

The mouse model showed defects in adult stem cell maintenance related to Hutchinson-Gilford progeria syndrome.

research Keratins as an Inflammation Trigger Point in Epidermolysis Bullosa Simplex

40 citations , November 2021 in “International Journal of Molecular Sciences”

Mutant keratins cause inflammation in Epidermolysis Bullosa Simplex, suggesting targeting them could help treat the disorder.

Skin Organoids Derived From NCSTN Mutated Patient-Induced Pluripotent Stem Cells Recapitulate Hidradenitis Suppurativa Pathogenic Hallmarks

research 545 Skin Organoids derived from NCSTN mutated patient-induced pluripotent stem cells recapitulate Hidradenitis Suppurativa pathogenic hallmarks

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin organoids with NCSTN mutation show changes in hair follicle development and higher inflammation, key features of Hidradenitis Suppurativa.

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community Blaming Finasteride doesn't help you solve anything: dry eyes

in Finasteride/Dutasteride 51 upvotes 1 year ago

Finasteride is debated for causing dry eyes, with some users experiencing relief after stopping it, while others find no connection. Topical treatments like dutasteride and minoxidil are suggested as alternatives, with advice to consult medical professionals.

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