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research Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice Overexpressing Spermidine/SpermineN 1-Acetyltransferase

124 citations , July 1997 in “Journal of Biological Chemistry”

Overexpressing a specific enzyme in mice causes hair loss and female infertility.

research Activated Polyamine Catabolism Depletes Acetyl-CoA Pools and Suppresses Prostate Tumor Growth in TRAMP Mice

91 citations , July 2004 in “Journal of Biological Chemistry”

Overexpressing SSAT enzyme reduces prostate tumor growth in mice.

research Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites

17 citations , July 2013 in “Amino Acids”

Increased ODC activity leads to skin tumors by recruiting stem cells, not by toxic byproducts.

research Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis

54 citations , February 2002 in “Carcinogenesis”

Increasing SSAT makes skin more prone to cancer.

research Relation of Skin Polyamines to the Hairless Phenotype in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase

54 citations , May 2001 in “Journal of Investigative Dermatology”

Excessive putrescine causes hair loss in transgenic mice by disrupting hair follicle development.

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