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research 269 The PPAR-γ modulator, N-acetyl-GED, protects from epithelial-mesenchymal-transition to human hair follicles: Potential relevance for scarring alopecia

September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

N-acetyl-GED may help prevent and partially reverse a process that leads to scarring hair loss.

Inhibition of Cholesterol Biosynthesis Modulates Epithelial-Mesenchymal Transition in Primary Cicatricial Alopecia Through TGFβ and Angiotensin Receptors

research Inhibition of Cholesterol Biosynthesis Modulates Epithelial-Mesenchymal Transition in Primary Cicatricial Alopecia Through TGFβ and Angiotensin Receptors

May 2023 in “Journal of Endocrinology and Reproduction”

Blocking cholesterol production may help control hair loss in Primary Cicatricial Alopecia by affecting key regulators.

Canonical and Dominant Negative Peroxisome Proliferator-Activated Receptor Gamma Isoforms Are Differentially Expressed in Human Skin and Skin Appendages

research 223 Canonical and Dominant Negative Peroxisome Proliferator-Activated Receptor γ Isoforms are Differentially Expressed in Human Skin and Skin Appendages

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Different types of PPARγ are found in varying amounts in human skin and its parts, which could affect how skin treatments work.

research The role of PPARγ-mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology

84 citations , February 2015 in “Experimental Dermatology”

PPARγ is crucial for skin health but can have both beneficial and harmful effects.

Cell of Origin Contributes to Melanoma Diversity

research 1379 Cell of origin contributes to the melanoma diversity

April 2018 in “Journal of Investigative Dermatology”

Different types of stem cells in the skin contribute to the variety of melanoma forms.

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community DHT Oily Scalp Dangers: Theory of an Oily Scalp and PPAR-GAMMA Dysregulation

in Research/Science 32 upvotes 1 year ago

Excessive scalp sebum, worsened by DHT, can lead to inflammation and hair loss, with clascoterone mentioned as a treatment. Diet changes seem ineffective for scalp sebum, and treatments like minoxidil and finasteride are suggested.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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