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GlossaryParaphenylenediamine (PPD)

chemical in hair dyes that can cause allergic reactions

Paraphenylenediamine (PPD) is a chemical commonly used in hair dyes to achieve long-lasting color. It is known for its ability to penetrate the hair shaft and provide a natural-looking color, but it can also cause allergic reactions in some individuals, leading to skin irritation or more severe responses.

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research 12-Chloracetyl-PPD, A Novel Dammarane Derivative, Shows Anti-Cancer Activity by Delaying G2/M Phase Cell Cycle Progression and Inducing ROS-Mediated Apoptosis

18 citations , December 2016 in “European journal of pharmacology”

A new compound slows cancer cell growth and causes cell death by blocking cell cycle progression and increasing cell-damaging molecules.

research Implication of MicroRNA Regulation in Para-Phenylenediamine-Induced Cell Death and Senescence in Normal Human Hair Dermal Papilla Cells

8 citations , March 2015 in “Molecular Medicine Reports”

Hair dye ingredient PPD causes cell death and aging in human hair cells by altering microRNA levels.

research A Review on Colorful Mehendi: The Risk of Paraphenylenediamine

1 citations , June 2019 in “Journal of Biological and Scientific Opinion”

PPD in mehendi can cause serious health problems and needs regulation.

research Patterns of Sensitization and Cross-Reactivity in Hair Dye Allergy: An 18-Year Tertiary-Center Experience from Greece

February 2026 in “PubMed”

Most hair dye allergies are caused by para-phenylenediamine (PPD), and safer hair dye options are needed.

research Apply Directly to the Forehead: Holmes, Nana, and Hennapecia

March 2007 in “The FASEB Journal”

Henna mixed with PPD can cause skin reactions, scarring, and a specific type of baldness, and needs more research to understand these effects.

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community allergen of the year award list(2000-2023).most allergens are in every day shampoos and skin care.

in Research/Science 4 upvotes 3 years ago

The post discusses allergens in everyday shampoos and skincare products, listing yearly allergens from 2000 to 2023. It suggests that these chemicals might contribute to acne and hair loss.

community Bee venom better than minoxidil?

in Research/Science 1061 upvotes 2 months ago

Bee venom at 0.001% concentration was more effective than 2% minoxidil in promoting hair growth in mice, possibly due to increased growth factors and reduced inflammation. Caution is advised due to potential allergic reactions and the reliance on animal data.

community I messed up. Regrew my hair and then lost it all.

in Update 495 upvotes 4 months ago

Stopping hair loss treatments like finasteride and minoxidil can result in losing regrown hair, highlighting the importance of consistent use. Restarting these treatments may cause temporary shedding, but hair can regrow with continued use.

community 1.5 years of Fin, switch 3 months ago to Dut, with 5 moths of Min too

in Progress Pictures 104 upvotes 3 years ago

User switched from Fin to Dut for better hair loss results, using 0.5mg Dut and 1ml Min daily. Some discuss potential side effects and benefits of Dut compared to Fin.