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5 / 1000+ resultsresearch JAK-Centric Explainable Few-Shot Gene-Expression Diagnosis Framework for Alopecia via MultiPLIER Priors and Relation-Style Set-to-Set Comparison
The study presents a novel diagnostic framework for alopecia areata (AA) using a few-shot deep learning classifier that integrates bulk and single-cell RNA-seq data to analyze JAK–STAT signaling. Researchers identified 257 differentially expressed genes in AA, with four key genes—GZMA, IL2RB, IL2RG, and EOMES—validated as biomarkers. The framework uses MultiPLIER latent variables and a Relation-style set-to-set comparator to distinguish AA from controls, even with limited samples, while maintaining interpretability. Functional validation confirmed the activation of the IL2RB/IL2RG–EOMES–GZMA axis in AA, linked to JAK inhibitors and cyclosporine, unlike androgenetic alopecia (AGA), which lacks JAK–STAT perturbation. This approach offers a non-invasive biomarker and a target for precision JAK blockade, demonstrating an XAI-driven method for small-cohort genomic diagnosis.
research Genetic Insights Into Acne, Androgenetic Alopecia, And Alopecia Areata: Implications For Mechanisms And Precision Dermatology
Genetic insights can lead to personalized treatments for acne, androgenetic alopecia, and alopecia areata.
research Advancements in Bioactive Compounds and Therapeutic Agents for Alopecia: Trends and Future Perspectives
New treatments for alopecia show promise in restoring hair growth by targeting immune and hormonal factors.
research Design and Characterization of Baricitinib Incorporated PLA 3D Printed Pills by Fused Deposition Modeling for Treating Alopecia Areata
The study created 3D-printed pills that effectively release a hair loss treatment drug over 24 hours.
research Montagna Symposium 2017—Precision Dermatology: Next Generation Prevention, Diagnosis, and Treatment
The symposium highlighted the importance of understanding disease mechanisms for targeted dermatology treatments.
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5 / 46 resultscommunity Suggestions for a good precision scale
The conversation is about finding a precise scale for measuring melatonin. The user needs to add 5mg per 100ml and finds Amazon scales imprecise.
community Where did this idea come from: dermastamp better than dermaroller?
Dermastamps are preferred over dermarollers for microneedling due to precision and reduced risk of scarring. Dermastamps allow for controlled, vertical needle entry, while dermarollers may cause more damage with sideways needle entry.
community Dermastamp or Dermaroller — which one is actually better?
The conversation discusses the effectiveness of dermastamps versus dermarollers for hair loss treatment, with some users preferring dermastamps for precision and less hair damage. One user reports using a dermastamp with minoxidil, while others mention the convenience of dermapens and the cost-effectiveness of dermarollers.
community How do you apply Tretinoin for Minoxidil extra results? (Apparently makes non responders respond)
People are discussing using tretinoin gel with minoxidil to improve hair growth, especially for those who didn't respond to minoxidil alone. They apply a mix of tretinoin gel and minoxidil to the scalp, which is said to be more effective than minoxidil by itself.
community how do you get tretinoin for hair? all I get is cream for the skin of the face
Mixing tretinoin gel with Minoxidil for hair application is discussed, with suggestions to mix per application to avoid clogging and degradation. Some users apply tretinoin cream to the hairline and use Minoxidil and finasteride, noting potential irritation on the crown.