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GlossaryProstaglandin D2 Synthase

enzyme converting prostaglandin H2 to prostaglandin D2, linked to hair loss

Prostaglandin D2 Synthase (PTGDS) is an enzyme that converts prostaglandin H2 into prostaglandin D2 (PGD2), a lipid compound involved in various physiological processes, including inflammation and allergic responses. In the context of hair biology, elevated levels of PGD2 have been linked to hair loss, particularly in conditions like androgenetic alopecia.

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Research

5 / 1000+ results

research In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss

30 citations , October 2015 in “Journal of Ethnopharmacology”

Herbal compounds like ricinoleic acid, quercetin-3-O-rutinoside, and hinokiflavone may be safe and effective for treating hair loss.

Prostaglandin D2, Prostaglandin D2 Receptor, Prostaglandin D2 Synthase

research Prostaglandin D2(PGD2); prostaglandin D2 receptor (CRTH2; GPR44; CD294); prostaglandin D2 synthase (PTGDS)

2 citations , April 2012 in “Science-business Exchange”

Blocking a protein called prostaglandin D2 might help treat hair loss.

Biochemical and Structural Characteristics, Gene Regulation, Physiological, Pathological and Clinical Features of Lipocalin-Type Prostaglandin D2 Synthase as a Multifunctional Lipocalin

research Biochemical and Structural Characteristics, Gene Regulation, Physiological, Pathological and Clinical Features of Lipocalin-Type Prostaglandin D2 Synthase as a Multifunctional Lipocalin

18 citations , October 2021 in “Frontiers in Physiology”

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

research Computer-Aided Designing Peptide Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase Combined Molecular Docking and Molecular Dynamics Simulation

9 citations , August 2023 in “Molecules”

Two peptides, RMYYY and VMYMI, may be effective anti-inflammatory drugs.

Oral Administration of Low-Dose Bisphenol A Promotes Proliferation of Ventral Prostate and Upregulates Prostaglandin D2 Synthase Expression in Adult Rats

research Oral administration of low-dose bisphenol A promotes proliferation of ventral prostate and upregulates prostaglandin D₂ synthase expression in adult rats

14 citations , June 2015 in “Toxicology and Industrial Health”

Low doses of BPA can increase prostate growth and change hormone levels in adult rats.

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community Doubts about castor oil

5 upvotes 7 years ago

Castor oil's effectiveness for hair growth is debated, with concerns about its impact on skin health and prostaglandin levels. Some users suggest combining it with coconut oil and using it alongside finasteride for better results, while others recommend sticking to proven synthetic treatments.

community 30-Min Dermatology Visit – Best Questions to Ask About Balding? ( 175$ )

in Treatment 6 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on finasteride, minoxidil, and other options like PRP and ketoconazole. It highlights the importance of asking specific questions during a dermatology visit to determine the cause of hair loss and appropriate treatments.

community Still not sure why men think diet has nothing to do with hair loss when scientific is quite the opposite [Link]

23 upvotes 8 years ago

Diet can influence hair health, but male pattern baldness (MPB) is primarily genetic. Treatments discussed include Minoxidil, finasteride, and RU58841.

community Zyrtec (Cetirizine) antihistamine for hair growth compared to Minoxidil NIH study

in Minoxidil 35 upvotes 3 years ago

The conversation discusses the potential of topical cetirizine (Zyrtec) for hair growth in comparison to minoxidil, noting cetirizine's ability to reduce prostaglandin D2, which inhibits hair growth. Users share mixed experiences with cetirizine for allergies and scalp health, and there's a mention of the risk of dementia with long-term antihistamine use.

community Need supplemental products in addition to oral minoxidil and oral dutasteride

in Product 1 upvotes 10 months ago

The user has been using oral minoxidil and dutasteride for hair loss without success and is considering adding topical 17α-estradiol, Pyrilutamide, Clascoterone, or cetirizine. They have confirmed low serum DHT levels and are exploring additional treatments due to genetic sensitivity to DHT and prostaglandin D2.

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learn Cetirizine

popular antihistamine showing promise for hair loss as an anti-inflammatory and prostaglandin inhibitor

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