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Single-Cell RNA Sequencing and Proteomic Analysis of Dermal Fibroblasts Cultured From Female Scalp Identifies Significant Alterations in Cell Populations With Age

research O21 Single-cell RNA sequencing and proteomic analysis of dermal fibroblasts cultured from female scalp identifies significant alterations in cell populations with age

July 2023 in “British journal of dermatology/British journal of dermatology, Supplement”

Aging changes scalp cells, possibly affecting hair health in older women.

research Plasma proteome–driven identification of druggable immune regulators of alopecia areata, validated by transcriptome and single-cell mapping

March 2026 in “Skin Appendage Disorders”

Belatacept may be a promising treatment for alopecia areata.

research Ultrahigh-Power Sonicator Lysis Enables Deep Proteomic Profiling of Hair Shafts for Fetal Growth Restriction Biomarker Discovery

November 2025 in “Analytical Chemistry”

A new method improves protein extraction from hair, helping identify potential biomarkers for fetal growth issues.

Sustained Exosome-Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and miRNAs, and Sustained Release Formulation

research Sustained Exosome‐Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and MiRNAs, and Sustained Release Formulation

40 citations , March 2022 in “Small”

Hydrogel with M2-derived exosomes improves wound healing by slowly releasing exosomes that help reduce inflammation and promote tissue repair.

research Divergent molecular signatures of regeneration and fibrosis during wound repair

3 citations , December 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Disrupting YAP signaling in skin cells leads to scar-free healing directed by specific cell signals.

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community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

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