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GlossaryProstaglandin D2 Synthase (PTGDS)

enzyme converting prostaglandin H2 to prostaglandin D2, linked to hair loss

Prostaglandin D2 Synthase (PTGDS) is an enzyme that converts prostaglandin H2 into prostaglandin D2 (PGD2), a lipid compound involved in various physiological processes, including inflammation and allergic responses. In the context of hair biology, elevated levels of PGD2 have been linked to hair loss, particularly in conditions like androgenetic alopecia.

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research Prostaglandin D2, Prostaglandin D2 Receptor, Prostaglandin D2 Synthase

2 citations , April 2012 in “Science-business Exchange”

Blocking a protein called prostaglandin D2 might help treat hair loss.

research Associations Between Variants in the Cyclooxygenase 2 Enzyme Gene (PTGS2) and Development of Benign Prostate Enlargement

November 2012 in “The Journal of Urology”

Certain gene variants may raise the risk of prostate enlargement, but taking NSAIDs could reduce this risk.

research The Prostaglandin Synthases, COX-2 and L-PGDS, Mediate Prostate Hyperplasia Induced by Low-Dose Bisphenol A

20 citations , August 2020 in “Scientific Reports”

Low-dose bisphenol A increases prostate size in rats by affecting certain enzymes.

research Structural and Functional Studies of L-PGDS and SMPDL3A Enzymes in Lipid Signaling Family

October 2019

L-PGDS has specific binding sites for its functions and could help in drug delivery system design.

research Bletilla Striata Polysaccharide Promotes Hair Growth and Suppresses Oxidative Stress and Senescence of Dermal Papilla Cells by Inhibiting Prostaglandin-Endoperoxide Synthase 2

January 2026 in “International Journal of Biological Macromolecules”

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community The additive effects of minoxidil and retinol

in Research/Science 9 upvotes 5 years ago

Retinoids, like Retin-A and retinol, can be beneficial when used with minoxidil for hair loss. Retin-A is the strongest and requires a prescription, while retinol is over-the-counter.

community Painkillers May Block Minoxidil

in Research/Science 15 upvotes 1 year ago

Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

community What should I expect from dutasteride?

in Finasteride/Dutasteride 2 upvotes 4 years ago

The user tried Minoxidil, PRP, Hair Carboxytherapy, and topical Dutasteride with limited success and is now on oral Dutasteride. They are experiencing some hair loss reduction but no significant density improvement, leading to feelings of depression.

community SETIPIPRANT PGE2 GROUP BUY AND PIONEERING HAIR GROWTH

6 upvotes 10 years ago

The conversation is about a user seeking help with hair regrowth treatments, specifically mentioning Setipiprant, Minoxidil, Finasteride, and RU58841. The user is trying to contact forum members for guidance on making and using these treatments.