learn Cyproterone
a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor
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5 / 801 resultslearn RU58841
a potent but unapproved and potentially problematic topical anti-androgen
learn Pyrilutamide
highly targeted anti-androgen that might have minimal systemic effects
learn Osteopontin
signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
learn Clascoterone
a novel topical treatment that inhibits DHT on androgen receptors
Research
5 / 1000+ results
research Endocrine Treatment of Transsexual Persons:An Endocrine Society Clinical Practice Guideline
The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.
research Endocrine care of transpeople part I. A review of cross-sex hormonal treatments, outcomes and adverse effects in transmen
Testosterone therapy is generally safe for transmen, improves sexual function, and has manageable health risks with proper monitoring.
research Care pathways of children and adolescents referred to specialist gender services: a systematic review
Many children and teens referred to gender services receive hormone treatments, but more research is needed on their long-term care and outcomes.
research Pharmacology of antiandrogens
Antiandrogens affect androgen-dependent body functions and are used for various medical conditions, with some risks like fetus feminization, but new forms like 17α-propylmesterolone show promise for acne without systemic effects.
research Recent advances in the molecular mechanisms causing primary generalized glucocorticoid resistance
Mutations in the NR3C1 gene cause a rare condition that affects hormone signaling and can lead to various symptoms, with dexamethasone as a treatment option.
Community Join
5 / 529 resultscommunity Why is scalp DHT suppression lower than systemic?
Dutasteride reduces DHT more effectively in hair follicles than finasteride, but some individuals still experience hair loss despite treatment. Combining oral and topical finasteride may improve results, and some users experiment with topical dutasteride despite uncertainties about its absorption.
community Finasteride and “anti-aging” effects
Finasteride may help users look younger by suppressing DHT, affecting skin and hair. Users also emphasize skincare, sunscreen, and lifestyle for maintaining a youthful appearance.
community Oral daily 1 mg dutasteride with Minoxidil topical solution
Oral dutasteride and topical Minoxidil are used to treat hair loss, with the goal of suppressing DHT and improving hair density. The effectiveness depends on genetics and the duration of baldness, and lifelong treatment may be necessary to maintain results.
community Any finasteride users who maintained their hair for over 15 years?
Many users have maintained their hair using finasteride, with some also using minoxidil or dutasteride, reporting minimal side effects. Opinions vary on the necessity of DHT, with some users arguing its importance beyond puberty, while others believe it is unnecessary and that finasteride and dutasteride are safe and effective for hair maintenance.
community The fact 2.5mg Dutasteride pills don't exist is f*cking ridiculous (RANT)
The conversation discusses the frustration over the unavailability of 2.5mg dutasteride soft gels, with some users suggesting higher doses for better scalp DHT suppression. Concerns about side effects and the necessity of DHT are debated, with some users advocating for alternative treatments like RU58841 and oral minoxidil.