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Dynamic Changes in Fibroblast Subpopulations Drive Development of Radiation-Induced Skin Fibrosis Through the Fra/c-Jun Pathway

research 1493 Dynamic changes in fibroblast subpopulations drives development of radiation-induced skin fibrosis through the fra/c-jun pathway

April 2023 in “Journal of Investigative Dermatology”

Radiation treatment causes skin fibrosis by increasing certain fibroblast subpopulations, but using a c-Jun inhibitor or fat grafting can reduce this effect.

research Radiotherapy-Induced Skin Fibrosis: Pathophysiology, Emerging Therapeutics, and the Role of Dermatology

February 2026 in “American Journal of Clinical Dermatology”

Radiotherapy can cause skin fibrosis, which is often overlooked and needs better treatment and evaluation.

research Accelerated senescence in skin in a murine model of radiation-induced multi-organ injury

19 citations , February 2017 in “Journal of radiation research”

High-dose radiation speeds up aging in skin stem cells.

research Establishment and characterization of a radiation‐induced dermatitis rat model

16 citations , February 2019 in “Journal of Cellular and Molecular Medicine”

Researchers created a rat model to study skin damage caused by radiation, which could help develop new treatments.

research Photobiomodulation therapy in management of cancer therapy-induced side effects: WALT position paper 2022

31 citations , August 2022 in “Frontiers in Oncology”

Photobiomodulation therapy helps manage cancer treatment side effects but needs more research for optimization.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Why do we have head hair in first place if we evolved to start losing it in some cases as soon as puberty hits

in Chat 138 upvotes 9 months ago

Hair loss is influenced by genetics and sensitivity to hormones like DHT. Treatments like Minoxidil and finasteride are commonly used, and baldness persists as it doesn't affect reproductive success.

community New molecule PP405 vs exercise

in Research/Science 38 upvotes 1 year ago

PP405 targets hair follicle stem cells differently than exercise-induced lactate, suggesting exercise alone may not replicate its benefits. Minoxidil and finasteride are recommended alongside exercise for hair regrowth, with additional suggestions like spicy food and infrared exposure.

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