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ROS-Responsive Hydrogel-Delivered miR-665 Targets STAT3 to Alleviate Inflammation and Promote Hair Follicle Regeneration in Alopecia Areata

research ROS-Responsive Hydrogel-Delivered miR-665 Targets STAT3 to Alleviate Inflammation and Promote Hair Follicle Regeneration in Alopecia Areata

February 2026 in “Journal of Nanobiotechnology”

A new treatment using a special gel with miR-665 reduces inflammation and helps hair regrow in alopecia areata.

Programmed Nanozyme Hydrogel Enabling Spatiotemporal Modulation of Wound Healing Achieves Skin Regeneration After Biofilm Infection

research Programmed Nanozyme Hydrogel Enabling Spatiotemporal Modulation of Wound Healing Achieves Skin Regeneration After Biofilm Infection

October 2025 in “Journal of Nanobiotechnology”

The hydrogel helps wounds heal better by reducing inflammation and promoting skin regeneration.

research Responsive Microneedles as a New Platform for Precision Immunotherapy

17 citations , May 2023 in “Pharmaceutics”

Microneedles can precisely deliver cancer treatments with fewer side effects.

research Biomembrane-Based Nanostructure and Microstructure Loaded Hydrogels for Promoting Chronic Wound Healing

24 citations , January 2023 in “International Journal of Nanomedicine”

Biomembrane-based hydrogels can effectively promote chronic wound healing.

research Smart Responsive Microneedles for Controlled Drug Delivery

22 citations , November 2023 in “Molecules”

Smart microneedles can deliver drugs painlessly and accurately for diseases like diabetes and tumors.

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Community Join

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community Hypoxia (lack of oxygen) enhances hair growth via stem cells

in Treatment 50 upvotes 1 year ago

Hypoxia may enhance hair growth by stimulating stem cells, but it could also risk fibrosis. Some users humorously discuss extreme methods like choking while using minoxidil, highlighting the need for new treatments.

community Possible topical option for preventing BDNF-related hair loss

in Research/Science 7 upvotes 2 years ago

The conversation discusses hair loss linked to BDNF-increasing nootropics like Semax and Lions Mane. Suggested topical treatments include capsaicin, beta-glucan, and ginseng to counteract TGF-B activation.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 737 upvotes 3 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

in Research/Science 122 upvotes 1 year ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

in Research/Science 46 upvotes 1 year ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.

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