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GlossaryReceptors

specialized proteins that bind specific molecules to trigger cellular responses

Receptors are specialized protein molecules found on the surface of cells or within cells that bind to specific substances, such as hormones, neurotransmitters, or drugs. When these substances attach to the receptors, they trigger a response within the cell, influencing various physiological processes. For example, in the context of hair biology, androgen receptors on hair follicle cells can bind to hormones like testosterone, affecting hair growth and potentially contributing to conditions like androgenetic alopecia (pattern baldness).

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Research

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research Receptor types in cat hairy skin supplied by myelinated fibers.

307 citations , November 1968 in “Journal of neurophysiology”

Cats' hairy skin has different touch receptors connected by myelinated fibers.

research Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse, and hamster.

164 citations , December 1984 in “Proceedings of the National Academy of Sciences”

TCDD reduces EGF receptor activity and causes various developmental changes in animals.

research Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction

119 citations , November 2014 in “Trends in Cell Biology”

Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

research Androgen receptor–mediated inhibition of cutaneous wound healing

108 citations , September 2002 in “The Journal of clinical investigation/The journal of clinical investigation”

Lowering testosterone speeds up wound healing in male mice.

Receptor Activator of NF-κB Stimulates the Proliferation of Epithelial Cells of the Epidermo-Pilosebaceous Unit

research Receptor activator of NF-κB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unit

60 citations , March 2011 in “Proceedings of the National Academy of Sciences of the United States of America”

RANK-RANKL signaling is essential for hair growth and skin health.

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Community Join

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community Fluridil degrades the androgen receptor.

in Research/Science 12 upvotes 1 year ago

Fluridil degrades androgen receptors, which are prevalent in the scalp and other tissues. People with androgenetic alopecia (AGA) may have higher expression of these receptors and 5AR activity in affected scalp areas.

community Dutasteride: More Than a DHT Reducer – A Potential Androgen Receptor Inhibitor?

in Finasteride/Dutasteride 31 upvotes 1 year ago

Dutasteride may inhibit androgen receptors in addition to reducing DHT, potentially explaining its effectiveness over finasteride for hair loss. Concerns about its impact on muscle growth are debated, with some suggesting no significant effects.

community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

community Fluridil downregulates androgen receptor expression?

in Research/Science 1 upvotes 2 years ago

Fluridil may decrease the number of androgen receptors in hair follicles by up to 95%. This suggests a different action mechanism from other non-steroidal antiandrogens like RU58841, indicating they might be used together.