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3α-AdiolG is a good marker for androgen activity in women with excessive hair growth and decreases with anti-androgen treatment.

Certain mutations in the hairless protein disrupt its ability to regulate the hair cycle.

A 3-year-old girl has a rare condition causing sparse hair and nail issues, with minimal improvement from treatment.

A new mutation in the HR gene is linked to a rare form of hair loss with limb deformities.

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

1,25-(OH)2D3 helps hair grow by blocking certain harmful signals.

New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.

Men might have a version of the female disease, polycystic ovarian syndrome, shown by changes in hormone levels and early baldness, but more research is needed to fully understand it.

Dietary L-serine supplementation can reduce symptoms of HSAN1 by lowering harmful 1-deoxySL levels.

Targeted therapy with Ustekinumab significantly improved a skin condition called ILVEN, which is caused by mutations in the CARD14 gene.

Insufficient androgen action in male fetuses can cause genital development issues due to genetic mutations or environmental chemicals.

A woman with childhood growth hormone deficiency had multiple hormone deficiencies and developed serious lung and kidney problems later in life.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

Accurate protein modeling can help develop new treatments for prostate cancer and other diseases.

A 15-year-old girl with rare reproductive disorders received hormone therapy to develop secondary sexual traits, but infertility persisted.

Compounds 15, 20, and 25 are strong inhibitors of human steroid 5α-reductase type 2.

A man with X-ALD improved after treatment, highlighting the need to consider X-ALD in similar patients and test their relatives.

The inhibitor DPP can promote hair growth.

A specific gene mutation causes Olmsted syndrome.

People with the same genetic mutation for Woodhouse-Sakati syndrome can have different symptoms.

Removing a specific gene in certain skin cells causes hair loss in mice by disrupting hair follicle development.

Compound 15a was effective in inhibiting 5α-reductase.

Restoring EDA and WNT pathways early may help improve skin, hair, and teeth issues in hypohidrotic ectodermal dysplasia.

Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

The mutant HR bmh protein affects hair follicle formation by failing to repress vitamin D receptor activity.

The vitamin D receptor can work without its usual activating molecule.