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Men and women respond differently to drugs for COVID-19, high cholesterol, and diabetes, which suggests a need for personalized treatments.

The method accurately measures seven androgens in plasma and shows different hormone levels in females with acne and obesity.

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

Certain compounds reduced hamster flank organ size by inhibiting 5α-reductase, like finasteride, without affecting androgen receptors.

New compounds may help treat prostate issues without affecting androgen receptors.

Metabolite 7 is a strong inhibitor for Alzheimer's disease management.

Androgens cause oil-producing skin cells with androgen receptors to mature and produce more oil.

The side gland of Suncus murinus is a good model for studying human sebaceous glands.

Removing a hormone-producing adrenal tumor can stop hair loss in women with high testosterone levels.

Inhibitors of the enzyme 5 alpha-reductase could potentially treat disorders like prostate cancer and baldness.

Dutasteride, usually used for prostate issues and hair loss, could potentially treat Amyotrophic Lateral Sclerosis (ALS) due to its neuroprotective, antioxidant, and anti-inflammatory properties, but more testing is needed.

5α-reductase inhibitors, like Finasteride and Dutasteride, help manage benign prostatic hyperplasia.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Gut bacteria can lower androgen levels in male mice.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

Saw palmetto extract may help with hair loss and acne but needs more research on safety and long-term effects.

High DHEA-S levels may cause hair loss in young men.

Leydig cells can cause testosterone-secreting adrenal tumors in women.

Dutasteride may protect the brain in early Parkinson's disease.

The method can measure multiple steroids in human hair to study long-term steroid metabolism, especially in newborns and children.

Androgens improve memory in adolescent male rats by acting on brain receptors.

Plant-derived amino acids can help develop new antimicrobial drugs.

Finasteride may lower cholesterol and slow heart disease progression.

Significant progress was made in understanding androgen excess disorders, but much is still unknown.

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

Testosterone and its metabolites affect brain functions and could help treat neurological disorders.

Microextraction techniques improve hormone testing while being environmentally friendly.

Hair steroid profiling is a feasible, non-invasive alternative to serum analysis for assessing hormone levels and metabolism.