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Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

research Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase

5 citations , February 1997 in “Bioorganic & Medicinal Chemistry”

New compounds were made that effectively block a specific enzyme related to androgen conditions.

research A new method for synthesis of finasteride

January 2011 in “Zhongguo xin yao zazhi”

A new, safer method to make finasteride from progesterone is effective for industrial use.

research [Anti-androgens. Their use in dermatology].

January 1981 in “PubMed”

Cyproterone acetate with ethynyl estradiol significantly improved acne and seborrhea in women, but was less effective for hair loss and excessive hair growth.

research 6 Peripheral androgens and the role of androstanediol glucuronide

57 citations , May 1986 in “Clinics in endocrinology and metabolism”

Androstanediol glucuronide is a reliable marker for hirsutism in women.

Pharmacokinetics and Bioconversion of Dehydroepiandrosterone After Dexamethasone Application in Women with Polycystic Ovary Syndrome

research Pharmacokinetics and Bioconversion of Dehydroepiandrosterone after Application of Dexamethasone in Women with Polycystic Ovary Syndrome

January 2004 in “Online Publication Service of Würzburg University (Würzburg University)”

Women with PCOS have higher 5alpha-reductase activity, affecting steroid levels.

research GC-MS determination of steroids related to androgen biosynthesis in human hair with pentafluorophenyldimethylsilyl–trimethylsilyl derivatisation

56 citations , January 1999 in “The Analyst”

The method accurately measures certain steroids in human hair, showing different levels in males and females.

research Design, synthesis and anti-tumor evaluation of novel thiohydantoin congeners as androgen receptor antagonists with in vivo study.

May 2024 in “Journal of molecular structure”

A new compound, 3a, effectively fights prostate cancer better than finasteride.

research 4 Anti-androgens in gynaecological practice

7 citations , September 1988 in “Baillière's clinical obstetrics and gynaecology”

Cyproterone acetate is effective for treating hirsutism and acne in women by blocking androgens in the skin and also works as a contraceptive.

research Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids

November 2023

New steroid derivatives show promise as anticancer agents, even against resistant cells.

research Theoretical Evaluation of Twenty-Cannabinoid Derivatives on Either Androgen Receptor or 5α-Reductase Enzyme

3 citations , January 2023 in “Clinical cancer investigation journal”

Some cannabinoid derivatives may be more effective than current drugs at targeting proteins relevant to prostate cancer treatment.

research The antiandrogen cyproterone acetate: discovery, chemistry, basic pharmacology, clinical use and tool in basic research^*

88 citations , July 2009 in “Experimental and Clinical Endocrinology & Diabetes”

research Is 3α, 17β-androstanediol-glucuronide a diagnostic marker in women with androgenic manifestations?

3 citations , January 1992 in “Gynecological Endocrinology”

3α, 17β-androstanediol-glucuronide is not a useful marker for androgen excess but may help monitor certain treatments.

research Molecular interactions of natural and synthetic steroids in female hamsters’ flank organs

1 citations , March 2012 in “Journal of Dermatological Science”

Testosterone, progesterone, and levonorgestrel change enzyme levels related to fat production in hamster skin, which could affect skin oil and acne.

research Clinical and metabolic effects of medroxyprogesterone acetate and ethinyl estradiol plus drospirenone in women with polycystic ovary syndrome

35 citations , July 2008 in “International Journal of Gynecology & Obstetrics”

MPA improved hormonal imbalances and acne in women with PCOS without affecting metabolism.

research The synthesis of (−)-4-methyl-8-chloro-trans-1,2,3,4,4a,5,6,10b-octahydrobenzo-[f]-quinolin-3-one-[3-14C] (LY300502-14C]) via a circuitous route

3 citations , October 1994 in “Journal of Labelled Compounds and Radiopharmaceuticals”

Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.

research BindingDB Entry 50021519: Discovery of (2S)-N-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment.

January 2025

Pharmacokinetics and Bioconversion of Dehydroepiandrosterone After Dexamethasone Pretreatment in Women With Polycystic Ovary Syndrome

research Pharmakokinetik und Biokonversion von Dehydroepiandrosteron nach Dexamethason-Vorbehandlung bei Frauen mit dem Syndrom der polyzystischen Ovarien

January 2004 in “Online Publication Service of Würzburg University (Würzburg University)”

Women with PCOS have higher 5alpha-reductase activity, affecting steroid levels.

research Use of Topical Minoxidil, 17α-Estradiol and Hydrocortisone Butyrate in Frontal Fibrosing Alopecia

1 citations , May 2014 in “European Journal of Inflammation”

A lotion with minoxidil, hydrocortisone butyrate, and 17a-estradiol can improve or stabilize Frontal Fibrosing Alopecia in some cases, but there's no universally-accepted treatment yet.

Biosynthesis of Dihydrotestosterone by a Pathway That Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line

research Biosynthesis of Dihydrotestosterone by a Pathway that Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line

36 citations , October 2009 in “Journal of Investigative Dermatology”

Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.

research Abietic Acid from Resina Pini of Pinus Species as a Testosterone 5.ALPHA.-Reductase Inhibitor

21 citations , January 2010 in “JOURNAL OF HEALTH SCIENCE”

Abietic acid from pine resin can effectively inhibit testosterone 5α-reductase.

In Vitro and In Vivo Effects of 17β-N-(4-Phenylcarbamoyl) Androst-4-en-3-one Derivatives as 5α-Reductase Inhibitors on Androgen-Dependent Glands

research In vitro and In vivo Effects of 17β-N-(4-phenylcarbamoyl) androst-4-en-3- one Derivatives as 5a-reductase Inhibitors on Androgen-dependent Glands

September 2020 in “Current Enzyme Inhibition”

Three compounds were found to inhibit a prostate disease-related enzyme and reduce prostate size more effectively than the current treatment, suggesting they could be used for treating benign prostatic hyperplasia.

Synthesis and Pharmacological Properties of Heterocyclic Steroids

research Miscellaneous Steroids

October 2010

The document concludes that scientists created various steroids with different properties, including a more effective semi-synthetic vitamin D.

Thrombotic Risk Minimization for Diane-35 and Generics

research Synthesis, Biological Evaluation and in silico Studies of Novel 5α-aza-Bhomo-3,5-secosteroids as Potential 5-reductase Inhibitors

October 2016 in “Letters in Drug Design & Discovery”

research Palmitoylethanolamide Stimulation Induces Allopregnanolone Synthesis in C6 Cells and Primary Astrocytes: Involvement of Peroxisome-Proliferator Activated Receptor-α

52 citations , May 2011 in “Journal of Neuroendocrinology”

PEA boosts allopregnanolone production and reduces oxidative stress in brain cells.

research Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications

23 citations , October 2008 in “Journal of medicinal chemistry”

PF-998425 is a new, effective, and non-phototoxic treatment for skin conditions related to androgens.

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