research Predominant expression of 5 alpha-reductase type 1 in pubic skin from normal subjects and hirsute patients.
The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.
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research ANDROGEN METABOLISM AS IT AFFECTS HAIR GROWTH IN ANDROGENETIC ALOPECIA
Androgens, like DHT, affect hair growth and treatments like finasteride may help.
research 13-cis-Retinoic Acid Affects Sheath-Shaft Interactions of Equine Hair Follicles in Vitro
research Relative efficacy of minoxidil and 5-alpha-reductase inhibitors in the treatment of male androgenetic alopecia: protocol for a network meta-analysis study
research Number of Hair Follicles Transplanted Times the Caliber of Hair — Expected Density
The expected density of a hair transplant depends on the number of hair follicles transplanted and the thickness of the hair.
research Finasteride—Low Risk to Fetuses
Finasteride is considered to have a low risk to fetuses.
research A finasteride patch for the treatment of androgenetic alopecia: A study of promoting permeability strategy using synthetic novel O-acylmenthols combined with ion-pair
The finasteride patch effectively treats hair loss by enhancing skin absorption.
research Androgen effects on the skin
Androgens like testosterone affect skin health and can lead to conditions such as acne and hair loss, with various treatments available.
research Assessment of Circulating Sex Steroid Levels in Prepubertal and Pubertal Boys and Girls by a Novel Ultrasensitive Gas Chromatography-Tandem Mass Spectrometry Method
Prepubertal girls have higher sex steroid levels than boys, possibly leading to earlier puberty.
research The effect of spironolactone on genital skin 5α-reductase activity
Spironolactone reduces the enzyme activity that converts testosterone to DHT, helping treat excessive hair growth in women.
research Antiandrogen Drugs Lower Serum Prostate-Specific Antigen (PSA) Levels in Hirsute Subjects: Evidence That Serum PSA Is a Marker of Androgen Action in Women1
Antiandrogen drugs can reduce PSA levels in women with excess hair, suggesting PSA is a sign of male hormone activity in women.
research Validated LC-MS/MS Method for Simultaneous Quantification of Finasteride in Human Plasma
research Contraindicated use of 5-alpha-reductase inhibitors in women
The document concludes that women should not use 5-alpha-reductase inhibitors due to the risk of birth defects and limited effectiveness.
research Testosterone in Women: Measurement and Therapeutic Use
Testosterone therapy can modestly improve sexual function in menopausal women but should be used cautiously and is not recommended for routine measurement in sexual dysfunction or hirsutism.
research Effects of androgen and valproic acid treatment on androgen- dependent cell line (LnCaP-SF)
research Association of 5-α reductase inhibitors and sexual dysfunction: A RADAR report
Using hair loss drugs finasteride and dutasteride may cause sexual side effects.
research Nanomilled Oral Testosterone Plus Dutasteride Effectively Normalizes Serum Testosterone in Normal Men With Induced Hypogonadism
A combination of nanomilled oral testosterone and dutasteride normalized testosterone levels in men with low testosterone and is safe for short-term use.
research SAHA syndrome: female androgenetic alopecia and hirsutism.
research Molecular docking of Vitamin D3 Receptor (VDR) with potential herbal substance as ligand to prevent excessive hair loss in menopausal women
Certain herbal compounds might help prevent hair loss in menopausal women by activating Vitamin D receptors.
research Structure of human type II 5 alpha-reductase gene
The human type II 5α-reductase gene has a specific structure important for understanding certain medical conditions.
research The Function of 5α-reductase in Related Diseases
5α-reductase enzyme affects hormone levels, influencing conditions like acne and hair loss.
research Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production
Diphenyl ethers can potentially reduce excess oil production when applied on the skin, helping treat conditions like acne.
research Phenyl Propanoid 1’s-1′-Acetoxychavicol Acetate Protects Against Testosterone-Induced Alopecia by Inhibiting Nadph Oxidase
ACA from Alpinia galanga may prevent testosterone-related hair loss.
research Minoxidil Multi-Component Crystals with Aromatic Carboxylic Acids: Theoretical Calculation and Structural Analysis
research Supplementary data: Treatment of androgenetic alopecia with sublingual minoxidil in transgender people receiving testosterone
research Supplementary data: Treatment of androgenetic alopecia with sublingual minoxidil in transgender people receiving testosterone
research LC-MS/MS improves screening towards 21-hydroxylase deficiency
LC-MS/MS is more reliable than immunoassays for diagnosing 21-hydroxylase deficiency.
research Supplementary data: Treatment of androgenetic alopecia with sublingual minoxidil in transgender people receiving testosterone
research Efeitos do tratamento prolongado de testosterona associado ao uso de algestona acetofenida e enantato de estradiol sobre o ciclo menstrual de fêmeas cativas de Sapajus libidinosus (macaco-prego)
The treatment changed hormone levels and increased sexual behavior in female capuchin monkeys.
research Inhibitors of 5α -Reductase Type I in LNCaP Cells from the Roots of Angelica koreana
Compounds from Angelica koreana roots, especially osthenol, could be effective for treating conditions like prostate disease and hair loss.