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The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

A woman's mature cystic teratoma caused her virilization by producing testosterone.

A woman with a specific mutation causing adrenal gland issues faced fertility problems, but careful hormone therapy helped her manage it successfully.

The substance MK386 effectively blocked testosterone conversion and reduced cell growth in certain skin cells, but inhibiting 5α-reductase alone may not greatly improve acne.

Inhibiting testosterone 5alpha-reductase may help treat benign prostatic hyperplasia.

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Finasteride may treat baldness but less effective for those with 5α-reductase deficiency.

A new method was developed to make a compound used in finasteride and epristeride with a 69% yield.

Women with acne have lower levels of a specific hormone marker than women without acne.

3βHSD2 is not useful for diagnosing PCOS.

The hHa7 gene is regulated by androgens in certain body hair, not scalp hair.

Finasteride effectively lowers specific hormone levels, helping monitor treatment progress.

Curcumin and its derivatives can block an enzyme important for making testosterone, with one derivative being particularly strong.

Scientists found out the structure of a human enzyme linked to prostate cancer and hair loss, which could help in designing drugs.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Glucocorticoids reduce fat production in liver cells, while androgens increase it in females; manipulating certain enzymes can influence these effects.

Genetic variations affect dutasteride treatment response for male pattern hair loss.

A new method was created to analyze certain chemicals in the urine of alopecia areata patients, revealing they have higher metanephrine content. This method can also be used for other related diseases.

New chemical compounds were made that effectively block an enzyme linked to prostate growth.

MK-386 lowers DHT in blood and skin but not in semen.

New compounds were made that effectively block a specific enzyme related to androgen conditions.

Omega-6 fats in certain cells boost male hormone production.

Urtica dioica extract may help treat androgenic skin diseases by reducing a specific gene's activity.

Testosterone and dihydrotestosterone play a role in women's health issues like excess hair and baldness, and treatments blocking these hormones may help.

The inhibitor DPP can promote hair growth.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

Alopecia indicates more severe resistance to 1,25-dihydroxyvitamin D.