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Synthesis and 5α-Reductase Inhibitory Activity of 8-Substituted Benzo[ƒ]Quinolinones Derived from Palladium Mediated Coupling Reactions

research Synthesis and 5α-reductase inhibitory activity of 8-substituted benzo[ƒ]quinolinones derived from palladium mediated coupling reactions

14 citations , February 1998 in “Bioorganic & Medicinal Chemistry Letters”

Some newly made compounds can block an enzyme linked to hair loss and prostate growth, with one in particular being very selective.

research Mineralocorticoid Receptor Antagonists Stimulate Human Hair Growth ex vivo

1 citations , January 2019 in “Skin Pharmacology and Physiology”

Eplerenone, a mineralocorticoid receptor antagonist, was found to promote hair growth in human hair follicles.

research Androgenic alopecia and hirsutism in a 73-year-old woman: careful re-evaluation of 'normal' imaging findings may lead to a rare diagnosis

May 2008

A 73-year-old woman's unusual hair loss and growth led to the discovery of a rare condition causing too much testosterone, which improved after her ovaries were removed.

research MANAGEMENT OF ENDOCRINE DISEASE Hyperandrogenic states in women: pitfalls in laboratory diagnosis

16 citations , February 2018 in “European Journal of Endocrinology”

Diagnosing hyperandrogenism in women is complex and requires accurate testing methods and consideration of SHBG levels.

research Clinical and Hormonal Evaluation of Androgen Excess

1 citations , November 2007 in “Humana Press eBooks”

Most cases of high male hormone levels in women are due to polycystic ovary syndrome.

research Steady-state pharmacokinetics of oral testosterone undecanoate with concomitant inhibition of 5α-reductase by finasteride

10 citations , October 2010 in “International Journal of Andrology”

Finasteride doesn't affect oral testosterone undecanoate, and high DHT levels may cause acne, prostate issues, and hair loss.

research Finasteride for hirsutism: a dose finding study.

8 citations , January 1998 in “PubMed”

research Induction of ornithine decarboxylase in specific subpopulations of murine epidermal cells following multiple exposures to 12-O-tetradecanoylphorbol-13-acetate, mezerein and ethyl phenylpropriolate

26 citations , January 1992 in “Carcinogenesis”

TPA strongly increases ODC activity in certain skin cells, potentially aiding tumor growth.

research Identification of 5α-reductase isoenzymes in canine skin

4 citations , July 2015 in “Veterinary Dermatology”

Two types of 5α-reductase are in dog skin, which might make dutasteride better than finasteride for treating dog hair loss.

research Hormonal Basis of Male and Female Androgenic Alopecia: Clinical Relevance

23 citations , January 1994 in “Skin Pharmacology and Physiology”

Hair loss in men and women is linked to high stress hormone levels and other hormonal imbalances, suggesting treatments should be customized to each person's hormones.

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