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Sex Steroid Synthesis in Human Skin In Situ: The Roles of Aromatase and Steroidogenic Acute Regulatory Protein in the Homeostasis of Human Skin

research Sex steroid synthesis in human skin in situ: The roles of aromatase and steroidogenic acute regulatory protein in the homeostasis of human skin

46 citations , May 2012 in “Molecular and Cellular Endocrinology”

Human skin produces sex hormones like estrogen and testosterone, influenced by ARO and StAR, which may affect skin elasticity and hair growth.

research Is There a Rationale for the Use of an Alpha-Melanocyte-Stimulating Hormone Analog to Improve Gray Hair Repigmentation?

November 2022 in “Skin Appendage Disorders”

PT-20 did not significantly improve gray hair repigmentation.

Efficacy and Tolerability of HDMHG0401-10 in Patients with Androgenetic Alopecia: A Randomized Double-Blind Placebo-Controlled Trial

research Efficacy and tolerability of HDMHG0401-10 in Patients with Androgenetic Alopecia-A Randomized Double-blind Placebo-controlled Trial

January 2005 in “Translational and Clinical Pharmacology”

HDMHG0401-10 improves hair loss in men with androgenetic alopecia and has no major side effects.

research Social Interest Data as a Proxy for Off-Label Performance-Enhancing Drug Use: Implications and Clinical Considerations

1 citations , January 2024 in “Curēus”

Clinicians should use social and prescription data to track trends in performance-enhancing drug use.

Synthesis and 5α-Reductase Inhibitory Activity of 8-Substituted Benzo[ƒ]Quinolinones Derived from Palladium Mediated Coupling Reactions

research Synthesis and 5α-reductase inhibitory activity of 8-substituted benzo[ƒ]quinolinones derived from palladium mediated coupling reactions

14 citations , February 1998 in “Bioorganic & Medicinal Chemistry Letters”

Some newly made compounds can block an enzyme linked to hair loss and prostate growth, with one in particular being very selective.

research Germacrene Analogs are Anti-androgenic on Androgen-dependent Cells

3 citations , September 2016 in “Natural Product Communications”

Germacrene analogs, especially 8-Hydroxy germacrene B, are more effective than germacrone at blocking a hormone-related enzyme and could help treat hair loss.

research Disorders in Male Sexual Differentiation Due to 5α-Reductase-2 Deficiency

January 2018 in “Elsevier eBooks”

5α-reductase-2 deficiency causes ambiguous genitalia at birth and affects male sexual development, but individuals often develop male characteristics at puberty.

research Crystal structure of Steroid 5-alpha-reductase 2 in complex with Finasteride

April 2020

research Mesotherapy With Dutasteride for Androgenetic Alopecia: A Retrospective Study in Real Clinical Practice.

July 2022 in “PubMed”

Mesotherapy with dutasteride effectively treats hair loss with manageable side effects.

Efficacy and Safety of Low-Dose Dutasteride for Male Androgenic Alopecia: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase III Clinical Trial

research Efficacy and Safety of Low-Dose (0.2 mg) Dutasteride for Male Androgenic Alopecia: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase III Clinical Trial

January 2025 in “Annals of Dermatology”

Low-dose dutasteride effectively and safely promotes hair growth in men.

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