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MK-386 lowers DHT in blood and skin but not in semen.

Allopregnanolone may help prevent nicotine withdrawal symptoms.

The method accurately measures testosterone metabolites with high sensitivity and low environmental impact.

Anabolic steroids and inflammation can disrupt androgen metabolism, potentially causing health issues.

The equine epididymis mainly uses type 1 5α-reductase, and both finasteride and dutasteride can inhibit its activity.

Progesterone and related compounds may help control seizures linked to the menstrual cycle but have limitations that need addressing.

GnRH-a or orchiectomy is more effective than anti-androgens for managing hormone levels in transgender women.

A woman's hyperandrogenism was caused by a genetic mutation leading to non-classic adrenogenital syndrome.

Women with PCOS have higher 5α-reductase activity, which may be linked to insulin resistance.

17β-estradiol lowers polyamine oxidase levels in breast cancer cells through estrogen receptor 2.

Dihydrotestosterone (DHT) is crucial for conditions like male-pattern baldness and acne, and measuring a byproduct, androstanediol glucuronide, is a better way to assess DHT's effects than DHT blood levels.

Cyproterone acetate is the preferred treatment for women's hyperandrogenism when estrogen/progestogen use is safe.

Finasteride 1 mg/day reduces semen quality without affecting hormones or sexual function.

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

High levels of testosterone and anti-Müllerian hormone before pregnancy are linked to a higher risk of newborns needing intensive care.

Cyproterone acetate is used to treat conditions like prostate cancer, early puberty, excessive sexual drive, and female androgenization by blocking male sex hormones.

Fetuin-A levels are higher in PCOS patients, suggesting it may play a role in the condition.

Treating PCOS patients with HP HMG significantly raises the risk of ovarian hyperstimulation syndrome, needing careful dose management.

Hair steroid profiling is a feasible, non-invasive alternative to serum analysis for assessing hormone levels and metabolism.

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.

Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.

Inhibiting testosterone 5alpha-reductase may help treat benign prostatic hyperplasia.

Low-dose oral contraceptives reduced hair growth and testosterone levels in women with polycystic ovary syndrome.

Prostaglandin D2 increases testosterone levels in skin cells through reactive oxygen species, not enzymes, which could lead to new hair loss treatments.

Hair analysis can effectively assess long-term hormone activity in young children.

Loestrin effectively normalizes testosterone levels and improves PCOS symptoms with minimal side effects.

DHEA therapy improves pubic hair growth and psychological well-being in young females with central adrenal insufficiency.

Compound 15a was effective in inhibiting 5α-reductase.

Both treatments reduced androgen levels and hair growth in women with hirsutism.