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Dihydrotestosterone (DHT) is crucial for conditions like male-pattern baldness and acne, and measuring a byproduct, androstanediol glucuronide, is a better way to assess DHT's effects than DHT blood levels.

Testosterone treatment in trans men increases body and facial hair and may lead to hair loss over time, but severe skin issues are rare.

Cyproterone acetate combined with ethinyl estradiol significantly reduced hirsutism in women.

New progesterone-based compounds can block male hormones.

Testosterone and letrozole treatment speeds up puberty in boys with delayed development.

Testosterone therapy seems safe for short-term use in postmenopausal women with low sexual desire, but more research on long-term effects is needed.

Testosterone works in different ways, including direct interaction with its receptor, conversion to other hormones for specific effects on genitalia, hair, bones, and muscle, and changes in body fat and sexual function when low.

Reducing 5α-reductase activity helps endometrial cells differentiate, aiding pregnancy.

Dihydrotestosterone gel improved well-being and sexual function in older men without negatively affecting prostate health.

Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.

Prostaglandin D2 increases testosterone production in skin cells through a process involving reactive oxygen species, and antioxidants may help treat hair loss.

Estrogens can reduce DHT production in hair follicles, but are less effective than finasteride and progesterone.

High doses of testosterone disrupt hormone levels and receptor expression in the uterus, affecting fertility.