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The severity of symptoms in nonclassical congenital adrenal hyperplasia is not determined by CYP21A2 gene variations.

Skin hormone levels change significantly after menopause.

Three specific 4-azasteroid-2-oximes showed strong enzyme inhibition, but less than finasteride.

Three siblings with a rare genetic condition had abnormal sexual development and chose different gender identities, needing surgery and therapy.

Vitamin D receptor is crucial for bone health and mineral metabolism.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

Neurosteroids are crucial for stress response, and targeting specific receptors may help treat certain disorders.

Finasteride may treat baldness but less effective for those with 5α-reductase deficiency.

New steroid compounds effectively inhibit 5α-reductase and may treat hair loss.

The compound was successfully made and shows potential for treating prostate cancer.

Glioblastoma cells can make androgens, which might help the tumor grow.

Steroids, particularly estrogens and 5α-reductase inhibitors, affect blood vessel-related hair growth processes in hair follicle cells.

Targeting impaired Nrf2 signaling might help treat hidradenitis suppurativa early on.

Enzyme purified and characterized for minoxidil sulphation in rat liver.

A 13-year-old girl's masculine symptoms improved after surgery for a rare adrenal tumor that produced male hormones.

A new gene mutation causes vitamin D-resistant rickets and hair loss in two siblings.

Androgens increase muscle mass by promoting myoblast growth through ornithine decarboxylase.

Hair steroid profiling is a feasible, non-invasive alternative to serum analysis for assessing hormone levels and metabolism.

ODC expression in mouse skin and tumors is varied and can be inhibited by retinoic acid or cycloheximide.

A mutation in the VDR gene affects hair cycling without needing ligand binding.

A new mutation in the DCAF17 gene was found in a Chinese family, causing Woodhouse-Sakati syndrome and diabetes.

New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.

Certain genetic variants impair enzyme activity, contributing to non-classic congenital adrenal hyperplasia.

Loss of COL17A1 causes hair follicle stem cells to age and leads to hair loss.

Bolandiol, a synthetic steroid, builds muscle and bone without greatly affecting sex glands, and works differently from other hormones.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.

Deleting the Sox21 gene changes hair lipid composition and increases cholesterol sulfate levels.