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The combination treatment reduced prostate size and improved testosterone deficiency symptoms but was less effective for sexual function.

Dutasteride improved both hair loss and acne in two young men.

The study found that different criteria led to different patient groups in the CombAT study compared to the MTOPS study.

Finasteride and dutasteride are effective for long-term treatment of enlarged prostates but have sexual side effects and a risk of high-grade prostate cancer.

The research gives new understanding on how human steroid 5α-reductases work and how drugs like finasteride inhibit them, which could help in creating new drugs.

Trapa bispinosa Roxb. extract may help reduce prostate size and cell growth in BPH.

Inhibiting testosterone 5alpha-reductase may help treat benign prostatic hyperplasia.

5-ARI therapy may help prevent prostate cancer progression.

Alfatradiol (0.025%) is an effective and safe treatment for hair loss in both women and men.

Loop diuretics may double bone loss in elderly men, finasteride lowers prostate cancer risk but may increase high-grade tumors, abarelix reduces testosterone quickly, and transdermal testosterone offers minimal sexual benefit for women.

Blocking a specific enzyme in male rat fetuses leads to the development of nipples and feminized genitalia.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

The compound GD-23 may reduce anxiety like diazepam by targeting the TSPO receptor.

5αR inhibitors help slow early prostate cancer cell growth, suggesting combined treatments are needed.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

Certain HSD3B1 gene types are linked to worse prostate cancer outcomes and affect treatment response and other health conditions.

Docetaxel slightly extends prostate cancer survival but has significant side effects and high cost.

Certain pesticides and fungicides can interfere with male hormone functions, potentially causing reproductive issues in male rats.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

A new treatment plan for hair loss combines targeted therapies and regenerative strategies to stabilize, reverse, and maintain hair growth.

Flutamide helps with prostate cancer and some skin conditions but can harm the liver.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

Scientists found out the structure of a human enzyme linked to prostate cancer and hair loss, which could help in designing drugs.

Glucocorticoids reduce fat production in liver cells, while androgens increase it in females; manipulating certain enzymes can influence these effects.

A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.

The equine epididymis mainly uses type 1 5α-reductase, and both finasteride and dutasteride can inhibit its activity.