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The vitamin D receptor has many roles in the body beyond managing calcium, affecting the immune system, hair growth, muscles, fat, bone marrow, and cancer cells.

A toddler with a rare adrenal gland tumor causing male-like physical changes was successfully treated with surgery.

Machine learning identified three unique subtypes of androgen excess in women with PCOS, each with different metabolic risks.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

PRO-C22 can help diagnose and monitor the severity of hidradenitis suppurativa.

Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.

A new genetic change in the DSC3 gene is linked to a rare condition causing hair loss and skin blisters in a child.

Certain mutations in the hairless protein disrupt its ability to regulate the hair cycle.

Adding a specific gene to skin cells can help treat skin disorders like psoriasis.

Diagnosing sex development disorders requires combining medical history, physical exams, imaging, lab tests, and genetic data.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

Vitamin D receptor helps control hair growth genes in skin cells.

Child with rickets improved with a specific vitamin D therapy, but alopecia did not change.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

Brothers of women with PCOS tend to have higher levels of a hormone called DHEAS, indicating a possible genetic link.

An over-the-counter vitamin/mineral supplement improved hair loss and blood sugar control in a woman with non-classic 11-hydroxylase deficiency.

Hepatitis B virus alters steroid hormones in male mice, reducing dihydrotestosterone to inhibit viral replication.

A woman with non-classic CAH had unusual heavy periods and high hormone levels, improved with treatment.

The enzyme that changes testosterone to a stronger form is mostly found in the part of the hair follicle called the dermal papilla.

Type 2 5α-reductase plays a key role in hair loss.

Dihydrotestosterone (DHT) is crucial for conditions like male-pattern baldness and acne, and measuring a byproduct, androstanediol glucuronide, is a better way to assess DHT's effects than DHT blood levels.

The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

Enzyme replacement therapy may help alleviate symptoms in complex cases like this.

A new gene mutation causes vitamin D-resistant rickets and hair loss in two siblings.

The document concluded that more research is needed to understand how estrogen affects the enzyme involved in hirsutism development.

Ovarian hyperthecosis should be considered in young women with severe male-like symptoms and can be managed with hormone treatments.

Women with PCOS have higher 5α-reductase activity, which may be linked to insulin resistance.

The document suggests treating individuals with nonclassic congenital adrenal hyperplasia who show symptoms, especially those related to excess male hormones.

Measuring androstanediol glucuronide in blood is useful for assessing and tracking treatment in women with excessive hair growth.

A new genetic mutation in the ODC1 gene causes developmental delay and other symptoms in a young girl.