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Immune cells in Hidradenitis suppurativa become more inflammatory and may be important for treatment targets.

Sex hormones may be linked to inflammation in Hidradenitis Suppurativa.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

Adrenomedullin 2 stops cell growth and causes cell death in human hair follicles.

HSL treatment speeds up hair growth and reduces oxidative stress in hair follicles of ob/ob mice.

Finasteride forms three new products under acidic stress.

Hsc70 protein may influence hair growth by responding to androgens.

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

A specific gene variation increases the risk of high uric acid and cholesterol in young Mexican males.

Enzyme activities do not cause early pubic hair in these girls.

Overexpression of SSAT causes hair loss and skin issues, but reducing putrescine can help.

The conclusion is that tritium-labeled testosterone metabolites can be made and are better converted into dihydrotestosterone in skin cells than in prostate tissue.

Using human recombinant hyaluronidase in donor strip harvesting may improve the procedure.

The enzyme is crucial for skin cell development and can be activated without proteolytic activation.

The tested hair dye ingredients do not form harmful oxidized metabolites in the liver.

Three specific mutations in the LIPH gene can cause hair loss by damaging the protein's structure and function.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Using β-cyclodextrin derivatives improves the solubility and bioavailability of steroidal drugs.

Higher PHGDH levels cause unusual melanin buildup in hair follicles.

A protein called desmoglein 3 is important for keeping hair follicle stem cells inactive and helps in their regeneration.

Using 5-butylpicolinate esters improves the sensitivity and reliability of detecting testosterone and dihydrotestosterone in saliva.

LSD1 is essential for healthy skin development and creating the skin's protective barrier.

A mutation in the hHb3 gene is linked to the hair disorder monilethrix.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Hidradenitis suppurativa may be a type of autoinflammatory skin disease linked to gene mutations and immune system issues.

Overexpressing SSAT in mice makes them highly sensitive to polyamine analogues, causing liver damage and high mortality.

Epristeride's metabolism involves key metabolites and proteins, affecting its use in doping tests.

Genetic mutations that disrupt homocysteine breakdown lead to increased damage in mouse hair keratin.