December 2025 in “The AAPS Journal” Finasteride and dutasteride's effects are mainly due to target binding saturation and slow enzyme turnover.
81 citations
,
June 2006 in “Experimental Neurology” Neurosteroids may help prevent seizures in epilepsy.
May 2023 in “IntechOpen eBooks” More research is needed to understand how testosterone is maintained in adult males.
March 2025 in “Carbohydrate Polymer Technologies and Applications” The new method improves finasteride's effectiveness for hair loss treatment.
8 citations
,
July 2021 in “F1000Research” Plant-based compounds might be a promising alternative for prostate cancer treatment with fewer side effects.
1 citations
,
March 2021 in “F1000Research” Plant-based compounds might be effective, low-side-effect treatments for prostate cancer by blocking a specific enzyme.
January 2026 in “Nature Reviews Urology”
January 2024 in “Journal of lipid research” Finasteride may lower cholesterol and slow heart disease progression.
111 citations
,
August 2015 in “Reviews in Endocrine and Metabolic Disorders” 5α-reductase inhibitors may cause persistent sexual dysfunction and depression, needing more research on long-term effects.
12 citations
,
December 2011
November 2023 in “Frontiers in Neuroendocrinology” Some people experience lasting sexual, psychological, and sleep problems after using finasteride or SSRI antidepressants, possibly due to similar underlying causes.
87 citations
,
April 1973 in “Endocrinology” The chemicals 17βC and its methyl ester can block the effects of testosterone on hamster skin but not the effects of DHT.
50 citations
,
May 2019 in “BioFactors” Pollution increases a compound in the skin that can lead to faster aging and more inflammation.
26 citations
,
July 2007 in “Biochemical Pharmacology” ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.
13 citations
,
April 1994 in “Baillière's clinical endocrinology and metabolism” Some people have genetic mutations that make them resistant to vitamin D, leading to rickets even with enough vitamin D intake.
11 citations
,
October 2024 in “Cell Death Discovery” 4-aminopyridine helps heal burn wounds faster by reducing inflammation and promoting new blood vessel growth.
11 citations
,
March 2009 in “Bioorganic & Medicinal Chemistry Letters” Chemicals called 4-(alkylthio)- and 4-(arylthio)-benzonitrile derivatives can potentially reduce oil production on skin, which could help treat conditions like acne and hair loss.
11 citations
,
August 2007 in “Bioorganic & Medicinal Chemistry Letters” Scientists made a chemical (compound 4e) that can be applied on skin to reduce oil production, which can help with acne, but it might cause skin sensitivity to light.
8 citations
,
March 2002 in “Archiv Der Pharmazie” The compound 4c effectively inhibits the enzyme linked to hair loss.
7 citations
,
September 1988 in “Baillière's clinical obstetrics and gynaecology” Cyproterone acetate is effective for treating hirsutism and acne in women by blocking androgens in the skin and also works as a contraceptive.
5 citations
,
February 2017 in “Biomolecules & Therapeutics” 4-O-Methylhonokiol helps protect skin cells from growth-stopping effects of a protein by regulating growth-related pathways.
3 citations
,
November 2011 in “European Journal of Dermatology” 4-O-methylhonokiol from Magnolia officinalis significantly promotes hair growth.
2 citations
,
December 2022 in “PNAS nexus” SCD-153 shows promise as an effective topical treatment for alopecia areata.
2 citations
,
June 2022 in “Journal of Applied Pharmaceutical Science” 4-O-Methylhonokiol from Magnolia shows promise for hair growth, cancer, diabetes, and more, but needs better absorption.
2 citations
,
February 2004 in “Biopolymers” 4-(4-Phenoxybenzoyl)benzoic acid derivatives can both increase and decrease certain types of reactive oxygen species, and may be relevant to hair loss.
1 citations
,
March 2024 in “Journal of Cellular and Molecular Medicine” 4-octyl itaconate may prevent hearing loss caused by the drug cisplatin by activating certain cell protection pathways.
1 citations
,
July 2017 in “Microbial Cell Factories” Adding soybean oil to Nonomuraea dietziae increases production of a beneficial compound by improving metabolism and enzyme systems.
January 2026 in “Journal of Cosmetic Dermatology” Topical 4-aminopyridine 5% does not improve hair growth in male pattern baldness.
4-Aminopyridine gel speeds up burn wound healing and improves skin regeneration.
December 2023 in “Redox biology” The substance DMC helps get rid of aging cells by triggering a process that causes cell death, which could treat age-related diseases.