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Glossary4-Methylaminorex

synthetic stimulant drug with effects similar to methamphetamine

4-Methylaminorex, also known as 4-MA or U4Euh, is a synthetic stimulant drug that has effects similar to methamphetamine. It was originally developed in the 1960s as an appetite suppressant but is now primarily known for its recreational use due to its euphoric and stimulating properties. It is classified as a Schedule I controlled substance in many countries, indicating a high potential for abuse and no accepted medical use.

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Discovery of 7-Methoxy-6-[4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazol-5-yl]-1,3-Benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

research Discovery of 7-Methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

6 citations , January 2013 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin”

A new compound shows promise as a topical treatment for hair loss.

research Low-level light-assisted photodynamic therapy using a wearable cap-like device for the treatment of actinic keratosis of the scalp

6 citations , November 2018 in “Photodiagnosis and Photodynamic Therapy”

A wearable cap-like device using light therapy reduced scalp skin lesions by 71% and was painless.

research 491 Efficacy of oral tofacitinib in the treatment of lichen planopilaris

1 citations , April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Oral tofacitinib significantly improves lichen planopilaris symptoms without adverse effects.

research 490 Samcyprone (diphenylcyclopropenone ointment) for the treatment of common warts

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Samcyprone ointment is effective for treating common warts if a sensitization reaction occurs first.

research Liposomes in dermatology today

140 citations , January 2009 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Liposomes improve drug delivery and reduce skin irritation in dermatology.

Photodynamic and Photobiological Effects of Light-Emitting Diode Therapy in Dermatological Disease: An Update

research Photodynamic and photobiological effects of light-emitting diode (LED) therapy in dermatological disease: an update

62 citations , July 2018 in “Lasers in Medical Science”

LED therapy is safe and shows potential for treating skin conditions and promoting hair growth, but more research is needed.

Erosive Pustular Dermatosis of the Scalp: A Multicenter Study

research Erosive pustular dermatosis of the scalp: a multicentre study

18 citations , January 2020 in “Journal of the European Academy of Dermatology and Venereology”

High-potency steroids or tacrolimus are effective treatments for Erosive Pustular Dermatosis of the Scalp.

The Impact of LED Therapy on Skin: A Review

research The Impact of LED Therapy on Skin: The Review

December 2025 in “Journal of Education Health and Sport”

LED therapy is safe and effective for improving skin health and appearance.

research Derma rollers in therapy: the transition from cosmetics to transdermal drug delivery

19 citations , October 2020 in “Biomedical Microdevices”

Derma rollers show promise for skin improvement and drug delivery, but more research is needed on their safety and effectiveness.

research The effects of narrowbands of visible light upon some skin disorders: a review

17 citations , December 2015 in “International Journal of Cosmetic Science”

Visible light can improve skin disorders and hair loss, but more research is needed to understand long-term effects.

research Alopecia Areata of the Beard: A Review of the Literature

16 citations , May 2017 in “American Journal of Clinical Dermatology”

The document concludes that more research is needed to understand and treat Beard Alopecia Areata due to limited current knowledge and evidence.

Vitamin D in Dermatology and Cosmetology

research Dermatoloji ve Kozmetolojide D Vitamini

June 2022

Vitamin D is crucial for skin health and managing skin diseases.

research Acne Protection: Measures & Miseries

January 2019 in “ARC journal of pharmaceutical sciences”

Acne can be managed with various treatments and requires psychological support due to its emotional impact.

research Dermatological drugs, topical agents, and cosmetics

January 2011 in “Side effects of drugs annual”

Tretinoin gel is safe for sun exposure, but tacalcitol doesn't significantly improve non-segmental vitiligo.

research Progress in Topical and Transdermal Drug Delivery Research—Focus on Nanoformulations

32 citations , June 2024 in “Pharmaceutics”

Nanoformulations improve drug delivery through the skin, reducing side effects and enhancing effectiveness.

research Alopecia Areata: Pathogenesis, Diagnosis, and Therapies

21 citations , April 2025 in “MedComm”

Alopecia areata causes unpredictable hair loss, and more research is needed to fully understand and treat it effectively.

research A Comprehensive Review of Acne Vulgaris

18 citations , June 2019 in “Clinical research in dermatology”

Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.

research Synthesis and 5α-Reductase Inhibitory Activity of C21 Steroids Having 1,4-diene or 4,6-diene 20-ones and 4-Azasteroid 20-Oximes

186 citations , December 2011 in “Molecules”

Three specific 4-azasteroid-2-oximes showed strong enzyme inhibition, but less than finasteride.

research The Antiandrogenic Action of 4–Androsten–3–one–17β– Carboxylic Acid and Its Methyl Ester on Hamster Flank Organ1

87 citations , April 1973 in “Endocrinology”

The chemicals 17βC and its methyl ester can block the effects of testosterone on hamster skin but not the effects of DHT.

research Involvement of 4‐hydroxy‐2‐nonenal in pollution‐induced skin damage

50 citations , May 2019 in “BioFactors”

Pollution increases a compound in the skin that can lead to faster aging and more inflammation.

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs

research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs

26 citations , July 2007 in “Biochemical Pharmacology”

ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.

research 13C-NMR study of 4-azasteroids in solution and solid state

25 citations , June 2002 in “Steroids”

4-azasteroids, including finasteride, can inhibit 5α-reductase, helping treat conditions like enlarged prostate and hair loss.

research New approach to 3-oxo-4-aza-5α-androst-1-ene-17β-(--butylcarboxamide)

14 citations , May 2005 in “Steroids”

A new method was developed to make finasteride for treating hair loss.

research 4 Vitamin D resistance

13 citations , April 1994 in “Baillière's clinical endocrinology and metabolism”

Some people have genetic mutations that make them resistant to vitamin D, leading to rickets even with enough vitamin D intake.

research 4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury in mice

11 citations , October 2024 in “Cell Death Discovery”

4-aminopyridine helps heal burn wounds faster by reducing inflammation and promoting new blood vessel growth.

4-(Alkylthio)- and 4-(Arylthio)-Benzonitrile Derivatives as Androgen Receptor Antagonists for the Topical Suppression of Sebum Production

research 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production

11 citations , March 2009 in “Bioorganic & Medicinal Chemistry Letters”

Chemicals called 4-(alkylthio)- and 4-(arylthio)-benzonitrile derivatives can potentially reduce oil production on skin, which could help treat conditions like acne and hair loss.

Preparation of 4-Aryl-2-Trifluoromethylbenzonitrile Derivatives as Androgen Receptor Antagonists for Topical Suppression of Sebum Production

research Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production

11 citations , August 2007 in “Bioorganic & Medicinal Chemistry Letters”

Scientists made a chemical (compound 4e) that can be applied on skin to reduce oil production, which can help with acne, but it might cause skin sensitivity to light.

Synthesis and Biological Evaluation of 4-(4-(Alkyl- and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-Steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2

research Synthesis and Biological Evaluation of 4-(4-(Alkyl-and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2

8 citations , March 2002 in “Archiv Der Pharmazie”

The compound 4c effectively inhibits the enzyme linked to hair loss.

research 4 Anti-androgens in gynaecological practice

7 citations , September 1988 in “Baillière's clinical obstetrics and gynaecology”

Cyproterone acetate is effective for treating hirsutism and acne in women by blocking androgens in the skin and also works as a contraceptive.

4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

research 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

5 citations , February 2017 in “Biomolecules & Therapeutics”

4-O-Methylhonokiol helps protect skin cells from growth-stopping effects of a protein by regulating growth-related pathways.