research Finasteride Treatment Inhibits Adult Hippocampal Neurogenesis in Male Mice
Finasteride reduces new brain cells in male mice, possibly causing depression.
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research Serum Androgens and Genetic Linkage Analysis in Early Onset Androgenetic Alopecia
Early onset hair loss linked to genetics and androgen levels.
research Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage
Androgen receptor signaling causes early aging of cells important for hair growth by damaging their DNA.
research The Use of Photodynamic Therapy for Treatment of Acne Vulgaris
Photodynamic Therapy is an effective treatment for mild to severe acne.
research Comparison of efficacy of platelet-rich plasma therapy with or without topical 5% minoxidil in male-type baldness: A randomized, double-blind placebo control trial
PRP combined with minoxidil is the most effective and safe treatment for male pattern baldness.
research An overview of herbal alternatives in androgenetic alopecia
Herbal alternatives like saw palmetto and green tea may offer safe, effective treatment for hormonal hair loss.
research 5α-Reductase inhibitors, antiviral and anti-tumor activities of some steroidal cyanopyridinone derivatives
Some newly made compounds are promising for treating enlarged prostate, hair loss, viruses, and prostate cancer, and might be better than current drugs.
research Hormone therapy in acne
Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.
research The Metabolism and Control Mechanism of Human Hair Follicles
Human hair follicles have a unique metabolism that changes between growth stages and may contribute to baldness.
research 5α-Reductase type 1 inhibition of Oryza sativa bran extract prepared by supercritical carbon dioxide fluid
Rice bran extract might help prevent hair loss.
research Inhibition of Inflammatory Gene Expression in Keratinocytes Using a Composition Containing Carnitine, Thioctic Acid and Saw Palmetto Extract
The composition with carnitine, thioctic acid, and saw palmetto extract may effectively reduce inflammation in hair follicle cells.
research Alopecia: unapproved treatments or indications
Many treatments for hair loss lack proper testing and FDA approval, so their effectiveness is uncertain.
research 5α-reductase activity in women with polycystic ovary syndrome: a systematic review and meta-analysis
Women with PCOS have higher 5α-reductase activity, which may be linked to insulin resistance.
research Anti-Androgen Effects of Extracts and Compounds fromGanoderma lucidum
Ganoderma lucidum may help treat prostate cancer by blocking male hormones and slowing cancer cell growth.
research New ester derivatives of dehydroepiandrosterone as 5α-reductase inhibitors
New compounds may help treat prostate issues without affecting androgen receptors.
research Finasteride for prostatic disease: an updated and comprehensive review
Finasteride helps treat prostate issues and may prevent prostate cancer in high-risk men.
research Subcellular localization of the five members of the human steroid 5α-reductase family
All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.
research Development of a Doxazosin and Finasteride Transdermal System for Combination Therapy of Benign Prostatic Hyperplasia
Researchers created a skin patch that delivers two drugs for treating enlarged prostate, which may improve patient use and dosage control.
research Urinary steroids in men with male-pattern alopecia
Men with male-pattern baldness have higher levels of certain testosterone metabolites and may have more active androgen metabolism.
research Exploring the Inhibitory Potential of Phytosterols β-Sitosterol, Stigmasterol, and Campesterol on 5-Alpha Reductase Activity in the Human Prostate: An In Vitro and In Silico Approach
Phytosterols may help manage prostate issues but are less effective than synthetic drugs.
research May patients receiving 5-alpha-reductase inhibitors be in higher risk of COVID-19 complications?
Men on 5-alpha-reductase inhibitors might have worse COVID-19 outcomes.
research Other Antiandrogens
Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.
research THERAPEUTIC HOTLINE: Treatment of androgenic alopecia with finasteride may result in a high grade prostate cancer in patients: fact or fiction?
Finasteride for hair loss is safe and does not increase the risk of high-grade prostate cancer.
research Male androgenetic alopecia (Part II)
Finasteride effectively treats male hair loss, increasing length and thickness.
research Pumpkin Seed Oil-Loaded Niosomes for Topical Application: 5α-Reductase Inhibitory, Anti-Inflammatory, and In Vivo Anti-Hair Loss Effects
Pumpkin Seed Oil in niosomes may help treat hair loss and improve hair growth.
research Penile vascular abnormalities in young men with persistent side effects after finasteride use for the treatment of androgenic alopecia
Finasteride for hair loss may cause lasting sexual, genitourinary, mental, and anti-androgenic side effects in young men.
research A comparative in vivo and in vitro evaluation of hair growth potential of extracts and an isolate from petroleum ether extract of Cuscuta reflexa Roxb
Cuscuta reflexa extracts and an isolate promoted hair growth and could be natural treatments for hair loss.
research Upregulation of mir-1199-5p is associated with reduced type 2 5-α reductase expression in benign prostatic hyperplasia
Higher levels of miR-1199-5p may reduce the effectiveness of certain prostate treatments.
research Effect of Saw Palmetto Supplements on Androgen-Sensitive LNCaP Human Prostate Cancer Cell Number and Syrian Hamster Flank Organ Growth
Saw palmetto supplements may reduce prostate cancer cell growth without being toxic.
research Anti-androgenetic alopecia effect of policosanol from Chinese wax by regulating abnormal hormone levels to suppress premature hair follicle entry into the regression phase
Policosanol helps treat hair loss by balancing hormones and supporting hair growth.