research 5α-Reduced glucocorticoids: a story of natural selection
Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.
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research Steroidogenic Isoenzymes in Human Hair and Their Potential Role in Androgenetic Alopecia
Steroidogenic isoenzymes may help improve treatments for common hair loss.
research Finasteride-induced depression: new insights into possible pathomechanisms
Finasteride may increase depression by reducing brain cell growth.
research Generation of comparative pharmacophoric model for steroidal 5α-reductase I and II inhibitors: A 3D-QSAR study on 6-azasteroids
The study created a model to help design new inhibitors for steroidal 5α-reductase enzymes.
research The corpus cavernosum after treatment with dutasteride or finasteride: A histomorphometric study in a benign prostatic hyperplasia rodent model
Dutasteride caused more penile tissue changes than finasteride, possibly increasing erectile dysfunction risk.
research Plants as potential active components in treatment of androgenetic alopecia
Plant extracts may help treat hormone-related hair loss.
research Activity of steroid 4 and derivatives 4a–4f as inhibitors of the enzyme 5α-reductase 1
Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.
research Effects of finasteride on the morphology of polycystic ovaries
Finasteride doesn't change polycystic ovary size or cyst number, suggesting testosterone's role in their appearance.
research Can beverages grow hair on bald heads?
Coffee and tea might help hair growth in balding individuals, but side effects and alternative uses are being considered.
research THU372 Finasteride Induced Hyperglycemia
Finasteride may worsen blood sugar control in diabetic patients.
research Anti-SARS-CoV-2 Action of 5α-Reductase Inhibitors May Be Mediated by Dehydroepiandrosterone. Letter.
Certain drugs like Dutasteride and Finasteride might help fight SARS-CoV-2 by increasing levels of a steroid called DHEA, which can protect the heart and increase nitric oxide to counteract the virus.
research Comprehensive Evaluation of Tectona grandis L.f.: Integrated In Vitro and In Silico Analysis of Steroid 5α-Reductase Inhibition and Anti-Inflammatory Properties
Teak leaf extract may help hair growth and reduce inflammation safely.
research Evaluation of hair growth-promoting, anti-inflammatory, and 5α-reductase inhibitory effects of Spirulina extract using in vitro and in vivo models
Spirulina extract may effectively promote hair growth and reduce inflammation, offering a natural alternative for hair loss treatment.
research Molecular Docking Studies and ADME-Tox Prediction of Phytocompounds from Punica granatum Peel as a Potential Anti-Alopecia Treatment
Pomegranate peel compounds may help treat hair loss.
research Analytical methods of dutasteride: An overview
Dutasteride is more effective than finasteride for hair loss treatment.
research Synthesis of avicequinone c and analogs toward the study of 5α-reductase inhibitory activity
2-Hydroxy-1,4-naphthoquinone is a strong 5α-reductase inhibitor.
research Finasteride para disminuir el sangrado en resección transuretral de próstata en pacientes con sonda Foley
Finasteride reduces bleeding during prostate surgery.
research Finasteride as a positive control on reproduction studies
Finasteride causes reproductive malformations in male rats.
research Paper 2. Epigallocatechin Gallate and Tannic Acid Based Formulations of Finasteride for Dermal Administration and Chemoembolization
Topical finasteride with EGCG or TA improves drug release and dermal uptake, potentially treating hair loss effectively.
research Current and Future Medical Treatment of Androgenetic Alopecia
Treatments for hair loss vary, but cell-based options may be the future.
research Alopecia: unapproved treatments or indications
Many treatments for hair loss lack proper testing and FDA approval, so their effectiveness is uncertain.
research Other Antiandrogens
Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.
research MECHANISM OF ACTION OF AVICENNIA MARINA HEARTWOOD EXTRACT AND AVICEQUINONE C ON HUMAN DERMAL PAPILLA CELLS ISOLATED FROM ANDROGENIC ALOPECIA PATIENTS
Avicennia Marina extract and avicequinone C can reduce hair loss hormone production and increase hair growth factors, suggesting they could be used to treat androgenic alopecia.
research Finasteride Treatment Inhibits Adult Hippocampal Neurogenesis in Male Mice
Finasteride reduces new brain cells in male mice, possibly causing depression.
research An overview of herbal alternatives in androgenetic alopecia
Herbal alternatives like saw palmetto and green tea may offer safe, effective treatment for hormonal hair loss.
research Acne
Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.
research The hair growth promoting effect of Sophora flavescens extract and its molecular regulation
Sophora flavescens extract may help hair grow by affecting growth factors and blocking a hair-related enzyme.
research Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum
The triterpenoids from Ganoderma lucidum can block testosterone effects and may help treat enlarged prostate.
research Skin steroidogenesis in health and disease
The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.
research Mechanism of action of herbs and their active constituents used in hair loss treatment
Some herbs and their components might help treat hair loss by affecting various biological pathways, but more research and regulation are needed.