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Did you mean Steroid 5 Alpha-Reductase 1?

GlossarySteroid 5 Alpha-Reductase 1

converts testosterone into a more potent androgen, dihydrotestosterone

Steroid 5 Alpha-Reductase 1 (SRD5A1) is an enzyme that converts testosterone into dihydrotestosterone (DHT), a more potent androgen hormone. This enzyme plays a significant role in the development of male characteristics and is also implicated in conditions like androgenic alopecia (male pattern baldness) and benign prostatic hyperplasia.

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research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases

218 citations , December 2011 in “Advances in Urology”

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Nonsteroidal Inhibitors of Human Type I Steroid 5α-Reductase

research Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase

89 citations , February 1993 in “Journal of Medicinal Chemistry”

New compounds called benzoquinolinones may treat conditions linked to excess DHT.

research The biochemical and phenotypic characterization of females homozygous for 5 alpha-reductase-2 deficiency.

54 citations , November 1995 in “The Journal of Clinical Endocrinology & Metabolism”

Females with 5 alpha-reductase-2 deficiency have less body hair, no acne, normal fertility, and delayed menarche.

research Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism.

33 citations , October 1994 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride reduces hair growth and is safe for women with excessive hair.

research Effects of finasteride, a 5 alpha-reductase inhibitor, on circulating androgens and gonadotropin secretion in hirsute women.

22 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride reduces dihydrotestosterone, increases testosterone, and may treat hirsutism in women.

research Synthesis and Pharmacological Evaluation of New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors

13 citations , January 2005 in “Chemical and Pharmaceutical Bulletin”

Smaller substituents at C-17 enhance the inhibitory activity of progesterone derivatives on 5alpha-reductase.

research Exploring the Inhibitory Potential of Phytosterols β-Sitosterol, Stigmasterol, and Campesterol on 5-Alpha Reductase Activity in the Human Prostate: An In Vitro and In Silico Approach

12 citations , November 2024 in “Plants”

Phytosterols may help manage prostate issues but are less effective than synthetic drugs.

research Predominant expression of 5 alpha-reductase type 1 in pubic skin from normal subjects and hirsute patients.

11 citations , May 1996 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

Changes in Serum Free Testosterone, Sleep Patterns, and 5-Alpha-Reductase Type I Activity Influence Sebum Excretion in Female Subjects

research Changes in serum free testosterone, sleep patterns, and 5‐alpha‐reductase type I activity influence changes in sebum excretion in female subjects

10 citations , August 2014 in “Skin research and technology”

Sleep, testosterone levels, and a specific enzyme activity affect skin oil production in women.

research Identification of Beta-Sitosterol and Stigmasterol as Possible Inhibitors of 5 Alpha-Reductase 1: An In-Silico Study

3 citations , January 2022 in “Precision medicine and clinical omics”

Beta-sitosterol and stigmasterol might help prevent hair loss by blocking a specific enzyme.

research Association Between 5-Alpha Reductase Inhibitor Use and The Risk of Depression: A Meta-Analysis.

3 citations , August 2020 in “Urology Journal”

Using 5-alpha reductase inhibitors may increase the risk of mild depression.

research Change in hair growth-related gene expression profile in human isolated hair follicles induced by 5-alpha reductase inhibitors – dutasteride and finasteride – in the presence of testosterone

1 citations , June 2021 in “Singapore Medical Journal”

Dutasteride and finasteride can help increase hair growth gene expression but need further improvement.

research Extensive Challenges and Pending Advances in the Study of 5-Alpha-Reductase Isoenzymes. A Literature Review

August 2024 in “Latin American Journal of Development”

5α-reductase enzymes are crucial in certain disorders, and while treatment advances exist, more research on SRD5A3 is needed.

Cloning, Computational Analysis and Expression Profiling of Steroid 5 Alpha-Reductase 1 (SRD5A1) Gene During Reproductive Phases and Ovatide Stimulation in Endangered Catfish, Clarias Magur

research Cloning, computational analysis and expression profiling of steroid 5 alpha-reductase 1 (SRD5A1) gene during reproductive phases and ovatide stimulation in endangered catfish, Clarias magur

November 2023 in “Scientific reports”

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

research Exploring the Potential of Eclipta alba: A Promising Approach for Hair Treatment Management through 5-Alpha Reductase Inhibition

June 2023 in “International journal of pharmaceutical quality assurance”

Eclipta alba extract could be a promising natural treatment for hair loss.

research Structure of human type II 5 alpha-reductase gene.

124 citations , September 1992 in “Endocrinology”

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

research Effects of 5-alpha reductase inhibitors on erectile function, sexual desire and ejaculation

71 citations , November 2012 in “Expert Opinion on Drug Safety”

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

Expression of mRNA for Androgen Receptor, 5α-Reductase, and 17β-Hydroxysteroid Dehydrogenase in Human Dermal Papilla Cells

research Expression of mRNA for androgen receptor, 5alpha-reductase and 17beta-hydroxysteroid dehydrogenase in human dermal papilla cells

63 citations , November 1999 in “British journal of dermatology/British journal of dermatology, Supplement”

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

research The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness.

59 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

research 5-Alpha reductase deficiency

38 citations , October 2014 in “Current Opinion in Endocrinology, Diabetes and Obesity”

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

research A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Postfinasteride Syndrome

35 citations , June 2018 in “Urology”

The review suggests younger men taking 1 mg finasteride report more side effects, including sexual, skin, metabolic, and psychological issues.

research Side Effects of 5‐Alpha Reductase Inhibitors: A Comprehensive Review

35 citations , April 2013 in “Sexual medicine reviews”

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

research Effect of finasteride, a 5 alpha-reductase inhibitor, on serum gonadotropins in normal men.

30 citations , August 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride doesn't affect hormone levels in normal men.

research Efficacy and safety of 5 alpha-reductase inhibitor monotherapy in patients with benign prostatic hyperplasia: A meta-analysis

19 citations , October 2018 in “PLOS ONE”

5 alpha-reductase inhibitors can slightly improve symptoms of enlarged prostate but have a high risk of sexual side effects.

The 5alpha-Reductase Type 1, But Not Type 2, Gene Is Expressed in Anagen Hairs Plucked from the Vertex Area of the Scalp of Hirsute Women and Normal Individuals

research The 5alpha-reductase type 1, but not type 2, gene is expressed in anagen hairs plucked from the vertex area of the scalp of hirsute women and normal individuals

17 citations , October 2003 in “Brazilian Journal of Medical and Biological Research”

The gene SDR5A1 is found in scalp hair of both hirsute and normal individuals, but it does not explain differences in hair growth.

research 5-Alpha-Reductase Inhibitors and Combination Therapy

15 citations , July 2016 in “Urologic Clinics of North America”

Finasteride and dutasteride are effective for long-term treatment of enlarged prostates but have sexual side effects and a risk of high-grade prostate cancer.

research Role of 5 alpha-reductase inhibitors in the management of prostate cancer

15 citations , December 2006 in “Clinical interventions in aging”

5 alpha-reductase inhibitors like finasteride may lower prostate cancer risk and improve cancer screening.

research Effects of the anti-androgen finasteride on 5alpha-reductase activity in human gingival fibroblasts in response to minocycline

15 citations , January 1998 in “Journal of Clinical Periodontology”

Finasteride helps treat hair loss by blocking enzyme activity.

research Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2

14 citations , April 2021 in “Biology”

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens

research Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens

12 citations , April 1995 in “Journal of Medicinal Chemistry”

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.