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Fadrozole and Finasteride change frog sex ratios and cause intersex animals with altered gene expressions.

Using 5-alpha-reductase inhibitors, drugs for prostate issues and hair loss, may lead to eye abnormalities in men.

DK peptides can reduce hair loss by inhibiting the 5α-reductase enzyme and have antioxidant effects.

Finasteride, when given in high oral doses to pregnant monkeys, caused genital abnormalities in male fetuses, but not in female fetuses or those exposed to intravenous finasteride.

5 alpha-reductase inhibitors can slightly improve symptoms of enlarged prostate but have a high risk of sexual side effects.

Using 5-alpha reductase inhibitors may increase the risk of mild depression.

The review found that women using hair loss drugs like finasteride and dutasteride rarely reported sexual side effects.

β-sitosterol and brassicasterol may help treat hair loss.

Prescriptions for 5-alpha reductase inhibitors dropped significantly after the FDA's safety warning, especially for men with benign prostatic hyperplasia.

Urologists prescribe newer medications more often than primary care physicians, who could benefit from more education on treatment options.

Finasteride works better than Permixon in reducing dihydrotestosterone levels.

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.

Dutasteride protects dopamine neurons in Parkinson's mice, but Finasteride doesn't.

Finasteride negatively affects fish reproduction and gonadal development.

A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.

BB4CMU rice bran oil may help treat hair loss and gray hair.

Fructus Psoraleae may help treat hair loss by inhibiting 5-α reductase and affecting the Nrf2-Keap1 pathway.

5-alpha reductase inhibitors do not increase hip fracture risk.

Finasteride effectively blocks enzyme causing male pattern baldness.

Finasteride affects male rat genitalia development, causing abnormalities during specific pregnancy days.

Finasteride helps treat hair loss and prostate enlargement by blocking a specific enzyme.

Combining 5α-reductase and aromatase inhibitors may better reduce estrogen levels.

Inhibiting 5α-reductase during late pregnancy shortens gestation, reduces litter size, and harms memory in rat offspring.

Finasteride helps protect brain in old male rats.

Finasteride raises suicide-linked aggression and stops clozapine's positive effects in schizophrenia animals.

Finasteride may cause kidney damage.

Finasteride reduces opioid use and withdrawal symptoms in animals.

Finasteride doesn't affect sleep spindles in men.

Purple corn extract may help reduce prostate enlargement and inflammation.

The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.