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Did you mean 5-alpha-reductase inhibitor?

Glossary5-alpha-reductase inhibitor

blocks enzyme converting testosterone to dihydrotestosterone (DHT)

A 5-alpha-reductase inhibitor is a type of medication that blocks the enzyme 5-alpha-reductase, which is responsible for converting testosterone into dihydrotestosterone (DHT). By reducing DHT levels, these inhibitors can help treat conditions like male pattern baldness and benign prostatic hyperplasia (BPH).

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research DIHYDROTESTOSTERONE AND THE PROSTATE: THE SCIENTIFIC RATIONALE FOR 5α-REDUCTASE INHIBITORS IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA

235 citations , September 2004 in “The Journal of urology/The journal of urology”

Drugs that block DHT production can effectively treat enlarged prostate and improve urinary issues with some sexual side effects.

research The Risks and Benefits of 5α-Reductase Inhibitors for Prostate-Cancer Prevention

147 citations , June 2011 in “New England journal of medicine/The New England journal of medicine”

5α-reductase inhibitors may prevent prostate cancer but could also raise the risk of more severe cancers.

A New Look at the 5-Alpha-Reductase Inhibitor Finasteride

research A New Look at the 5?-Reductase Inhibitor Finasteride

137 citations , March 2006 in “Cns Drug Reviews”

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production

research Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production

124 citations , March 2012 in “JAMA”

Testosterone's muscle-building effects do not require its conversion to DHT.

research Association of Suicidality and Depression With 5α-Reductase Inhibitors

90 citations , March 2017 in “JAMA Internal Medicine”

Men over 66 taking medication for prostate enlargement have a higher risk of depression and self-harm, especially in the first 18 months of treatment.

research 5-Alpha Reductase Inhibitors and Erectile Dysfunction: The Connection

78 citations , December 2008 in “The Journal of Sexual Medicine”

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction, but the exact reasons are unclear.

research Effects of 5-alpha reductase inhibitors on erectile function, sexual desire and ejaculation

71 citations , November 2012 in “Expert Opinion on Drug Safety”

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

research Effects of finasteride, a type 2 5-alpha reductase inhibitor, on fetal development in the rhesus monkey (Macaca mulatta)

67 citations , February 1997 in “Teratology”

Finasteride, when given in high oral doses to pregnant monkeys, caused genital abnormalities in male fetuses, but not in female fetuses or those exposed to intravenous finasteride.

The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

research The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness.

59 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

research Effect of 5α-Reductase Inhibitors on Sexual Function: A Meta-Analysis and Systematic Review of Randomized Controlled Trials

57 citations , July 2016 in “The Journal of Sexual Medicine”

5α-reductase inhibitors increase the risk of sexual dysfunction, especially in men with enlarged prostate.

research Selective non-steroidal inhibitors of 5α-reductase type 1

49 citations , January 2004 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

research 5 Alpha-reductase inhibitors: whatʼs new?

47 citations , January 2003 in “Current opinion in urology”

A new drug, dutasteride, is at least as effective as the older drug, finasteride, for treating enlarged prostate and may have additional uses.

Overexpression of Aldo-Keto Reductase 1C3 in LNCaP Cells Diverts Androgen Metabolism Towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride

research Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride

45 citations , January 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

5-Alpha-Reductase Inhibitors for Prostate Cancer Chemoprevention: An Updated Cochrane Systematic Review

research 5-α-Reductase inhibitors for prostate cancer chemoprevention: an updated Cochrane systematic review

44 citations , October 2010 in “BJUI”

5-α-reductase inhibitors reduce prostate cancer risk but may cause sexual dysfunction and don't affect high-grade tumor or death rates.

research 5‐alpha‐reductase inhibitors are associated with reduced frequency of COVID‐19 symptoms in males with androgenetic alopecia

36 citations , November 2020 in “Journal of The European Academy of Dermatology and Venereology”

5-alpha-reductase inhibitors may reduce COVID-19 symptoms in bald males.

research A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Postfinasteride Syndrome

35 citations , June 2018 in “Urology”

The review suggests younger men taking 1 mg finasteride report more side effects, including sexual, skin, metabolic, and psychological issues.

research Side Effects of 5‐Alpha Reductase Inhibitors: A Comprehensive Review

35 citations , April 2013 in “Sexual medicine reviews”

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

Curcuma Aeruginosa, A Novel Botanically Derived 5α-Reductase Inhibitor In The Treatment Of Male-Pattern Baldness: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study

research Curcuma aeruginosa, a novel botanically derived 5α-reductase inhibitor in the treatment of male-pattern baldness: a multicenter, randomized, double-blind, placebo-controlled study

34 citations , July 2011 in “Journal of Dermatological Treatment”

Curcuma aeruginosa extract combined with minoxidil effectively treats male-pattern baldness.

Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque

research Hair growth effects of oral administration of finasteride, a steroid 5 alpha-reductase inhibitor, alone and in combination with topical minoxidil in the balding stumptail macaque.

34 citations , February 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride and minoxidil together promote hair growth better than either alone.

research Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome

33 citations , January 2016 in “Skin appendage disorders”

The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.

research Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism.

33 citations , October 1994 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride reduces hair growth and is safe for women with excessive hair.

research Adverse Effects and Safety of 5-alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review.

32 citations , July 2016 in “PubMed”

5-alpha reductase inhibitors are generally safe but can cause sexual side effects and require patient education on risks.

research Male Breast Cancer and 5α-Reductase Inhibitors Finasteride and Dutasteride

32 citations , May 2013 in “The Journal of Urology”

Using finasteride or dutasteride does not increase the risk of male breast cancer.

research The Effect of 5 -Reductase Inhibitors on Erectile Function

31 citations , September 2008 in “International Journal of Andrology”

5-alpha-reductase inhibitors may cause a low incidence of erectile dysfunction that decreases over time.

Risk of Erectile Dysfunction Associated with Use of 5-Alpha Reductase Inhibitors for Benign Prostatic Hyperplasia or Alopecia: Population-Based Studies Using the Clinical Practice Research Datalink

research Risk of erectile dysfunction associated with use of 5-α reductase inhibitors for benign prostatic hyperplasia or alopecia: population based studies using the Clinical Practice Research Datalink

30 citations , September 2016 in “BMJ”

Taking 5-α reductase inhibitors for prostate enlargement or hair loss does not significantly raise the risk of erectile dysfunction.

Incomplete Recovery of Erectile Function in Rats After Discontinuation of Dual 5-Alpha Reductase Inhibitor Therapy

research Incomplete Recovery of Erectile Function in Rat after Discontinuation of Dual 5‐Alpha Reductase Inhibitor Therapy

29 citations , July 2012 in “The Journal of Sexual Medicine”

Rats had lasting erectile problems after stopping a certain medication.

research Long-term use of 5α-reductase inhibitors and the risk of male breast cancer

28 citations , August 2014 in “Cancer Causes & Control”

Taking 5α-reductase inhibitors does not significantly increase the risk of breast cancer in men.

research Benzo[c]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1

28 citations , September 2000 in “Journal of Medicinal Chemistry”

Benzo[c]quinolizin-3-ones are effective nonsteroidal inhibitors of human steroid 5α-reductase 1.

research 12 Treatment of hirsutism with 5α-reductase inhibitors

28 citations , May 1986 in “Clinics in endocrinology and metabolism”

New compounds may soon be tested to treat excessive hair growth in women.

A Population-Based Nested Case-Control Study: The Use of 5-Alpha-Reductase Inhibitors and the Increased Risk of Osteoporosis Diagnosis in Patients with Benign Prostate Hyperplasia

research A population‐based nested case–control study: the use of 5‐alpha‐reductase inhibitors and the increased risk of osteoporosis diagnosis in patients with benign prostate hyperplasia

22 citations , August 2014 in “Clinical endocrinology”

Taking finasteride for benign prostate hyperplasia may increase the risk of osteoporosis, especially at higher doses.