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Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

Spironolactone reduces the enzyme activity that converts testosterone to DHT, helping treat excessive hair growth in women.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Inhibitors of the enzyme 5 alpha-reductase could potentially treat disorders like prostate cancer and baldness.

Certain drugs change freshwater snail shells to a "banana" shape.

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

Finasteride modifies 5-alpha-reductases through a two-step process, affecting inhibitor potency and possibly causing side effects.

Finasteride works better than Permixon in reducing dihydrotestosterone levels.

Finasteride reduces hair growth and is safe for women with excessive hair.

Finasteride reduces movement issues in Parkinson's disease rats.

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

Taking 5-alpha reductase inhibitors does not increase the risk of breast cancer in men.

A Saudi individual initially identified as a girl had a genetic disorder affecting gender development.

Eclipta alba extract could be a promising natural treatment for hair loss.

The gene SDR5A1 is found in scalp hair of both hirsute and normal individuals, but it does not explain differences in hair growth.

Smaller substituents at C-17 enhance the inhibitory activity of progesterone derivatives on 5alpha-reductase.

Taking 5-Alpha Reductase Inhibitors before bladder removal surgery might make high-grade bladder tumors less aggressive.

Using 5-alpha reductase inhibitors may increase the risk of mild depression.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

Medications for enlarged prostate can cause sexual side effects like reduced libido, erectile dysfunction, and ejaculatory problems.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

Alstonia boonei phytochemicals show promise as alternative treatments for BPH with fewer side effects than current drugs.

The developed model can predict effective 5-alpha-reductase enzyme inhibitors.

Medicines for enlarged prostate may raise the risk of breast growth and tenderness but not breast cancer.

12-Methoxy carnosic acid from rosemary might be a good natural treatment for hair loss.

The models can help find better inhibitors for conditions like baldness and prostate disorders.